HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 128

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HXB2 Location gp160(38-48)
gp120(38-48)
DNA(6336..6368)
gp160 Epitope Map
Author Location gp120(45-55)
Epitope VYYGVPVWKEA Epitope Alignment
VYYGVPVWKEA epitope logo
Species (MHC/HLA) mouse(H-2bxk, H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 129

Download this epitope record as JSON.

HXB2 Location gp160(38-48)
gp120(38-48)
DNA(6336..6368)
gp160 Epitope Map
Author Location Env(45-55)
Epitope VYYGVPVWKEA Epitope Alignment
VYYGVPVWKEA epitope logo
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Nehete1993 P. N. Nehete, W. C. Satterfield, C. M. Matherne, R. B. Arlinghaus, and K. J. Sastry. Induction of Human Immunodeficiency Virus-Specific T Cell Responses in Rhesus Monkeys by Synthetic Peptides from gp160. AIDS Res. Hum. Retroviruses, 9:235-240, 1993. Notes: Three rhesus monkeys were immunized with eight synthetic peptides that induce T cell activity in mice. PBMCs from these monkeys were monitored every 2 weeks for 34 weeks for proliferative responses against individual peptides and gp160. PubMed ID: 8471313. Show all entries for this paper.


Displaying record number 130

Download this epitope record as JSON.

HXB2 Location gp160(38-48)
gp120(38-48)
DNA(6336..6368)
gp160 Epitope Map
Author Location Env(45-55)
Epitope VYYGVPVWKEA Epitope Alignment
VYYGVPVWKEA epitope logo
Species (MHC/HLA) chimpanzee, human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Nehete1998a P. N. Nehete, S. J. Schapiro, P. C. Johnson, K. K. Murthy, W. C. Satterfield, and K. J. Sastry. A Synthetic Peptide from the First Conserved Region in the Envelope Protein gp160 Is a Strong T-Cell Epitope in HIV-Infected Chimpanzees and Humans. Viral Immunol., 11:147-158, 1998. PubMed ID: 9918406. Show all entries for this paper.


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