Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201148

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HXB2 Location	Vpu(6-20) DNA(6077..6121)	Vpu Epitope Map
Author Location	Vpu(6-20 clade B consensus)
Epitope	VLAIVALVVATIIAI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Brazil
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA cross-presentation, chronic infection

Notes

• TEPITOPE algorithm was used to screen the most conserved regions of clade B consensus sequence for multiple HLA-DR binding epitopes. Peptides predicted to bind 16 or more HLA-DR molecules were synthesized and further assessed in binding assays and for T-cell recognition in a cohort of 32 Brazilian HIV-1 chronically infected individuals.

References

Fonseca2006 Simone G Fonseca, Adriana Coutinho-Silva, Luiz Augusto M. Fonseca, Aluisio C. Segurado, Sandra L. Moraes, Hélcio Rodrigues, Juergen Hammer, Esper G. Kallás, John Sidney, Alessandro Sette, Jorge Kalil, and Edecio Cunha-Neto. Identification of Novel Consensus CD4 T-Cell Epitopes from Clade B HIV-1 Whole Genome That Are Frequently Recognized by HIV-1 Infected Patients. AIDS, 20(18):2263-2273, 28 Nov 2006. PubMed ID: 17117012. Show all entries for this paper.