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Displaying record number 201179

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HXB2 Location	Gag(390-400) p2p7p1p6(27-37) DNA(1957..1989)	Gag Epitope Map
Author Location	Gag(390-400)
Epitope	VKCFNCGKGEH	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	India
Experimental methods	CD4 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	subtype comparisons

Notes

• T cell responses to Gag consensus C peptides were studied in C-infected patients from India. CD8+ responses were stronger and broader than CD4+ responses. IFN-γ response was higher in both CD8+ and CD4+ T cells than corresponding IL-2 response, that was detectable only in CD4+ T cells.
• 1/25 patients responded to this peptide (IFN-γ CD4+ response). IL-2 response was not detectable.

References

Kaushik2005 S. Kaushik, M. Vajpayee, N. Wig, and P. Seth. Characterization of HIV-1 Gag-Specific T Cell Responses in Chronically Infected Indian Population. Clin. Exp. Immunol., 142(2):388-397, Nov 2005. PubMed ID: 16232229. Show all entries for this paper.