HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 201533

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location Gag(297-311 HXB2)
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Subtype B
Species (MHC/HLA) transgenic mouse(DRB1*01:01)
Immunogen vaccine
Experimental methods T-cell Elispot
Keywords vaccine-induced immune responses, dendritic cells

Vaccine Details

Vaccine type DNA prime with peptide boost, DNA
Vaccine strain B clade HXB2
Vaccine component Gag

Notes

References

Simon2010 Gregory G. Simon, Yongli Hu, Asif M. Khan, Jingshi Zhou, Jerome Salmon, Priya R. Chikhlikar, Keun-Ok Jung, Ernesto T. A. Marques, and J. Thomas August. Dendritic Cell Mediated Delivery of Plasmid DNA Encoding LAMP/HIV-1 Gag Fusion Immunogen Enhances T Cell Epitope Responses in HLA DR4 Transgenic Mice. PLoS One, 5(1):e8574, 2010. PubMed ID: 20052293. Show all entries for this paper.


Displaying record number 201286

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location Gag(297-311 SF2)
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Epitope Name Peptide 75
Subtype B
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB
Vaccine component Gag, Tat
Adjuvant Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

References

Cellini2008 Silvia Cellini, Cinzia Fortini, Eleonora Gallerani, Federica Destro, Egidio Brocca Cofano, Antonella Caputo, and Riccardo Gavioli. Identification of New HIV-1 Gag-Specific Cytotoxic T Lymphocyte Responses in BALB/c Mice. Virol. J., 5:81, 2008. PubMed ID: 18625037. Show all entries for this paper.


Displaying record number 201626

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location p24
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Epitope Name Gag-VQ15
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD4 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords subtype comparisons, computational epitope prediction

Notes

References

Buggert2012 Marcus Buggert, Melissa M. Norström, Chris Czarnecki, Emmanuel Tupin, Ma Luo, Katarina Gyllensten, Anders Sönnerborg, Claus Lundegaard, Ole Lund, Morten Nielsen, and Annika C. Karlsson. Characterization of HIV-Specific CD4+ T Cell Responses Against Peptides Selected with Broad Population and Pathogen Coverage. PLoS One, 7(7):e39874, 2012. PubMed ID: 22792193. Show all entries for this paper.


Displaying record number 201634

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location p24
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Species (MHC/HLA) human
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development

Notes

References

Bozzacco2012 Leonia Bozzacco, Haiqiang Yu, Jörn Dengjel, Christine Trumpfheller, Henry A. Zebroski, 3rd, Nawei Zhang, Victoria Küttner, Beatrix M. Ueberheide, Haiteng Deng, Brian T. Chait, Ralph M. Steinman, Svetlana Mojsov, and David Fenyö. Strategy for Identifying Dendritic Cell-Processed CD4+ T Cell Epitopes from the HIV Gag p24 Protein. PLoS One, 7(7):e41897, 2012. PubMed ID: 22860026. Show all entries for this paper.


Displaying record number 201992

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location Gag
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Epitope Name Gag 297S
Species (MHC/HLA) human, mouse
Immunogen in vitro stimulation or selection, HIV-1 infection, vaccine
Country China
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding, Other
Keywords binding affinity, vaccine-induced immune responses, kinetics, vaccine antigen design

Vaccine Details

Vaccine type polyepitope, E. coli recombinant protein
Vaccine component Env, Gag, Nef, Pol

Notes

References

Shu2020 Jiayi Shu, Wei Shen, Haitao Liu, Yiqing Zhou, Jianhui Li, Yan Zhuang, Zhenghui Huang, Shigang Yin, Lubin Jiang, Yongtao Sun, Xia Jin, and Jianqing Xu. The Immunologic Dominance of an Epitope within a Rationally Designed Poly-Epitope Vaccine Is Influenced by Multiple Factors. Vaccine, 38(14):2913-2924, 23 Mar 2020. PubMed ID: 32127225. Show all entries for this paper.


Displaying record number 201930

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location Gag
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Epitope Name Gag297S
Species (MHC/HLA) humanized mouse, mouse
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Notes

References

Liu2017 Haitao Liu, Wei Shen, Jiayi Shu, Zhihua Kou, and Xia Jin. A Novel Polyepitope Vaccine Elicited HIV Peptide Specific CD4+ T Cell Responses in HLA-A2/DRB1 Transgenic Mice. PLoS One, 12(9):1-11, 2017. PubMed ID: 28863168. Show all entries for this paper.


Displaying record number 201276

Download this epitope record as JSON.

HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location Gag(297-311)
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Chromium-release assay, Th support of CTL response
Keywords vaccine-induced immune responses, Th1, Th2

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB, B clade SF162
Vaccine component Gag, gp120, gp140ΔV2
Adjuvant Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

References

Gavioli2008 Riccardo Gavioli, Silvia Cellini, Arianna Castaldello, Rebecca Voltan, Eleonora Gallerani, Francesca Gagliardoni, Cinzia Fortini, Egidio Brocca Cofano, Chiara Triulzi, Aurelio Cafaro, Indresh Srivastava, Susan Barnett, Antonella Caputo, and Barbara Ensoli. The Tat Protein Broadens T Cell Responses Directed to the HIV-1 Antigens Gag and Env: Implications for the Design of New Vaccination Strategies against AIDS. Vaccine, 26(5):727-737, 30 Jan 2008. PubMed ID: 18096278. Show all entries for this paper.


Displaying record number 201420

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HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location p24
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA OM296:
Country Canada
Experimental methods CD4 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords acute/early infection

Notes

References

Jones2009 R. Brad Jones, Feng-Yun Yue, Xiao Xiao Jenny Gu, Diana V. Hunter, Shariq Mujib, Gabor Gyenes, Rosemarie D. Mason, Ruqaya Mohamed, Kelly S. MacDonald, Colin Kovacs, and Mario A. Ostrowski. Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4+ T-Cell Responses without High-Frequency Fixation of Mutations. J. Virol., 83(17):8722-8732, Sep 2009. PubMed ID: 19553327. Show all entries for this paper.


Displaying record number 201077

Download this epitope record as JSON.

HXB2 Location Gag(297-311)
p24(165-179)
DNA(1678..1722)
Gag Epitope Map
Author Location Gag(297-311 HXB-2)
Epitope VDRFYKTLRAEQASQ Epitope Alignment
VDRFYKTLRAEQASQ epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA DQB1*06:02, DQB1*06:04, DRB1*13:02, DRB1*15:01, DRB3*03:01, DRB5*01:01; DQB1*03:01, DQB1*06:01, DRB1*13:03, DRB1*15:02, DRB3*01:01, DRB5*01:02; DQB1*03:01, DRB1*04:01, DRB1*11:01, DRB3*02:02, DRB4*01:03; DQB1*02:02, DQB1*06:02, DRB1*07:01, DRB1*15:01, DRB4*01:03, DRB5*01:01
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords  

Notes

References

Koeppe2006 John R. Koeppe, Thomas B. Campbell, Eric L. Rapaport, and Cara C. Wilson. HIV-1-Specific CD4+ T-Cell Responses Are Not Associated With Significant Viral Epitope Variation in Persons With Persistent Plasma Viremia. J. Acquir. Immune Defic. Syndr., 41(2):140-148, 1 Feb 2006. PubMed ID: 16394844. Show all entries for this paper.


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