Search T Helper/CD4+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 164

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HXB2 Location	gp160(199-211) gp120(199-211) DNA(6819..6857)	gp160 Epitope Map
Author Location	gp120(204-216)
Epitope	SVITQACSKVSFE	Epitope Alignment
Species (MHC/HLA)	mouse(H-2bxk, H-2sxd)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• Peptides induced T-cell proliferative response in mice representing four haplotypes.

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.

Displaying record number 165

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HXB2 Location	gp160(199-211) gp120(199-211) DNA(6819..6857)	gp160 Epitope Map
Author Location	Env(204-216)
Epitope	SVITQACSKVSFE	Epitope Alignment
Species (MHC/HLA)	macaque
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• Synthetic peptide derived from conserved region of the HIV-1 envelope that stimulates a proliferative response in mice.
• A weak or transient proliferative response to this peptide was observed in 3/3 immunized rhesus monkeys.

References

Nehete1993 P. N. Nehete, W. C. Satterfield, C. M. Matherne, R. B. Arlinghaus, and K. J. Sastry. Induction of Human Immunodeficiency Virus-Specific T Cell Responses in Rhesus Monkeys by Synthetic Peptides from gp160. AIDS Res. Hum. Retroviruses, 9:235-240, 1993. Notes: Three rhesus monkeys were immunized with eight synthetic peptides that induce T cell activity in mice. PBMCs from these monkeys were monitored every 2 weeks for 34 weeks for proliferative responses against individual peptides and gp160. PubMed ID: 8471313. Show all entries for this paper.

Displaying record number 166

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HXB2 Location	gp160(199-211) gp120(199-211) DNA(6819..6857)	gp160 Epitope Map
Author Location	Env(204-216)
Epitope	SVITQACSKVSFE	Epitope Alignment
Species (MHC/HLA)	chimpanzee, human
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• HIV-infected chimpanzees and HIV-positive patients show positive proliferative responses to multiple peptides from five conserved regions of the HIV-1 Env.

References

Nehete1998a P. N. Nehete, S. J. Schapiro, P. C. Johnson, K. K. Murthy, W. C. Satterfield, and K. J. Sastry. A Synthetic Peptide from the First Conserved Region in the Envelope Protein gp160 Is a Strong T-Cell Epitope in HIV-Infected Chimpanzees and Humans. Viral Immunol., 11:147-158, 1998. PubMed ID: 9918406. Show all entries for this paper.