Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201212

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HXB2 Location	Gag(38-53) p17(38-53) DNA(901..948)	Gag Epitope Map
Author Location	p17(270-284)
Epitope	SRELERFALNPSLLEE	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Proliferation
Keywords	vaccine antigen design

Vaccine Details

Notes

• Healthy volunteers were immunized with a vaccine containing clade A consensus gag plus a string of immunodominant CD8+ epitopes from the gag, pol, nef and env genes. 12/16 vaccinees produced T-cell responses mainly mediated by CD4+ T cells. Of the responders, 11/12 developed responses to previously-identified CD4+ epitopes, and 5/12 also developed CD8+ T-cell responses to the epitope string.
• 4/8 subjects responded to this epitope.

References

Goonetilleke2006 Nilu Goonetilleke, Stephen Moore, Len Dally, Nicola Winstone, Inese Cebere, Abdul Mahmoud, Susana Pinheiro, Geraldine Gillespie, Denise Brown, Vanessa Loach, Joanna Roberts, Ana Guimaraes-Walker, Peter Hayes, Kelley Loughran, Carole Smith, Jan De Bont, Carl Verlinde, Danii Vooijs, Claudia Schmidt, Mark Boaz, Jill Gilmour, Pat Fast, Lucy Dorrell, Tomas Hanke, and Andrew J. McMichael. Induction of Multifunctional Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T Cells Capable of Proliferation in Healthy Subjects by Using a Prime-Boost Regimen of DNA- and Modified Vaccinia Virus Ankara-Vectored Vaccines Expressing HIV-1 Gag Coupled to CD8+ T-Cell Epitopes. J. Virol., 80(10):4717-4728, May 2006. PubMed ID: 16641265. Show all entries for this paper.