Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 201475

Download this epitope record as JSON.

HXB2 Location	Gag(384-401) p2p7p1p6(21-38) DNA(1939..1992)	Gag Epitope Map
Author Location	Gag
Epitope	RNQRKTVKCFNCGKEGHI	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Germany, United States
Experimental methods	Flow cytometric T-cell cytokine assay
Keywords	elite controllers

Notes

• The study demonstrated that HIV-1-specific IL-21 CD4+ T cell responses might contribute to the control of viral replication in humans. Specifically, triggering of IL-21 by CD4+ T cells was significantly enriched in HIV-1 controllers, while loss of IL-21-secreting CD4+ was characteristic for subjects with persistent viremia and progressive disease. Expansion of IL-21 CD4+ T cells in acute infection resulted in lower viral set points. IL-21 production by CD4+ T cells of HIV controllers enhanced perforin production by HIV-1-specific CD8+ T cells from chronic progressors even in late stages of disease, and effector CD8+ T cells were more efficient in inhibiting viral replication in vitro after IL-21 binding.
• This peptide belongs to a set of overlapping peptides spanning HIV Gag. It elicited both IL-21 and IFN-γ secretion in one HIV controller.

References

Chevalier2011 Mathieu F. Chevalier, Boris Jülg, Augustine Pyo, Michael Flanders, Srinika Ranasinghe, Damien Z. Soghoian, Douglas S. Kwon, Jenna Rychert, Jeffrey Lian, Matthias I. Muller, Sam Cutler, Elizabeth McAndrew, Heiko Jessen, Florencia Pereyra, Eric S. Rosenberg, Marcus Altfeld, Bruce D. Walker, and Hendrik Streeck. HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function. J. Virol., 85(2):733-741, Jan 2011. PubMed ID: 21047960. Show all entries for this paper.