HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 20 matching records:

Displaying record number 205

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human(DR)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Baier1995 G. Baier, G. Baier-Bitterlich, D. J. Looney, and A. Altman. Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J. Virol., 69:2357-2365, 1995. PubMed ID: 7533857. Show all entries for this paper.


Displaying record number 201

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) mouse(H-2 Ad)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Takahashi1990 H. Takahashi, R. N. Germain, B. Moss, and J. A. Berzofsky. An Immunodominant Class I-Restricted Cytotoxic T Lymphocyte Determinant of Human Immunodeficiency Virus Type 1 Induces CD4 Class II-Restricted Help for Itself. J. Exp. Med., 171:571-576, 1990. Notes: This same epitope can be recognized in the context of a class I MHC D$^d$, by CD4- CD8+ CTL, and in the context of a class II MHC A$^d$ by CD4+ CD8- T-helper cells. PubMed ID: 1689366. Show all entries for this paper.


Displaying record number 204

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) mouse(H-2 I-Ad)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Takeshita1995 T. Takeshita, H. Takahashi, S. Kozlowski, J. D. Ahlers, C. D. Pendleton, R. L. Moore, Y. Nakagawa, K. Yokomuro, B. S. Fox, D. H. Margulies, and J. A. Berzofsky. Molecular Analysis of the Same HIV Peptide Functionally Binding to Both a Class I and a Class II MHC Molecule. J. Immunol., 154:1973-1986, 1995. Of RGPGRAFVTI, the upper case amino acids iGPgRaFvtI are critical for binding, consistent with H-2D$d$ motif XGPX(RKH)XXX(X)(LIF). Stimulation of the HLA class II I-A$^d$ required a longer peptide, IQRGPGRAFVTI or RIQRGPGRAFVTI, and riqrgPgRaFvti were essential for binding to the Class II molecule. PubMed ID: 7530749. Show all entries for this paper.


Displaying record number 213

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1997 M. Clerici, S. Piconi, C. Balotta, D. Trabattoni, A. Capetti, M. L. Fusi, S. Ruzzante, R. Longhi, M. C. Colombo, M. Moroni, and F. Milazzo. Pentoxifylline Improves Cell-Mediated Immunity and Reduces Human Immunodeficiency Virus (HIV) Plasma Viremia in Asymptomatic HIV-Seropositive Persons. J. Infect. Dis., 175:1210-1215, 1997. PubMed ID: 9129088. Show all entries for this paper.


Displaying record number 200535

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18IIIB
Subtype B
Species (MHC/HLA)  
Immunogen HIV-1 exposed seronegative
Experimental methods Cytokine production
Keywords  

Notes

References

Clerici1994 M. Clerici, J. M. Levin, H. A. Kessler, A. Harris, J. A. Berzofsky, A. L. Landay, and G. M. Shearer. HIV-Specific T-Helper Activity in Seronegative Health Care Workers Exposed to Contaminated Blood. JAMA, 271(1):42-46, 5 Jan 1994. PubMed ID: 8258885. Show all entries for this paper.


Displaying record number 211

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Clerici1991b M. Clerici, C. O. Tacket, C. S. Via, D. R. Lucey, S. C. Muluk, R. A. Zajac, R. N. Boswell, J. A. Berzofsky, and G. M. Shearer. Immunization with Subunit Human Immunodeficiency Virus Vaccine Generates Stronger T Helper Cell Immunity than Natural Infection. Eur. J. Immunol., 21:1345-1349, 1991. Notes: Immunization of uninfected individuals with an HIV subunit vaccine results in stronger Th cell immunity than does natural infection. Boosting enhances helper function. Env epitopes: T1, T2, TH4.1, P18. PubMed ID: 1845391. Show all entries for this paper.


Displaying record number 201003

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location Env (gp160)(317-331 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods Proliferation
Keywords responses in children

Notes

References

Meddows-Taylor2004 Stephen Meddows-Taylor, Maria A. Papathanasopoulos, Louise Kuhn, Tammy M. Meyers, and Caroline T. Tiemessen. Detection of Human Immunodeficiency Virus Type 1 Envelope Peptide-Stimulated T-Helper Cell Responses and Variations in the Corresponding Regions of Viral Isolates among Vertically Infected Children. Virus Genes, 28(3):311-318, Apr 2004. PubMed ID: 15266112. Show all entries for this paper.


Displaying record number 216

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp160(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Wasik1999 T. J. Wasik, J. Bratosiewicz, A. Wierzbicki, V. E. Whiteman, R. R. Rutstein, S. E. Starr, S. D. Douglas, D. Kaufman, A. V. Sison, M. Polansky, H. W. Lischner, and D. Kozbor. Protective Role of beta-Chemokines Associated with HIV-Specific Th Responses against Perinatal HIV Transmission. J. Immunol., 162:4355-4364, 1999. PubMed ID: 10201969. Show all entries for this paper.


Displaying record number 202

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Nehete1993 P. N. Nehete, W. C. Satterfield, C. M. Matherne, R. B. Arlinghaus, and K. J. Sastry. Induction of Human Immunodeficiency Virus-Specific T Cell Responses in Rhesus Monkeys by Synthetic Peptides from gp160. AIDS Res. Hum. Retroviruses, 9:235-240, 1993. Notes: Three rhesus monkeys were immunized with eight synthetic peptides that induce T cell activity in mice. PBMCs from these monkeys were monitored every 2 weeks for 34 weeks for proliferative responses against individual peptides and gp160. PubMed ID: 8471313. Show all entries for this paper.


Displaying record number 203

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, Th1, Th2

Notes

References

Wasik1997 T. J. Wasik, P. P. Jagodzinski, E. M. Hyjek, J. Wustner, G. Trinchieri, H. W. Lischner, and D. Kozbor. Diminished HIV-Specific CTL Activity Is Associated with Lower Type 1 and Enhanced Type 2 Responses to HIV-Specific Peptides during Perinatal HIV Infection. J. Immunol., 158:6029-6036, 1997. PubMed ID: 9190958. Show all entries for this paper.


Displaying record number 207

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18-IIIB
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, Cytokine production
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Pinto1995 L. A. Pinto, J. Sullivan, J. A. Berzofsky, M. Clerici, H. A. Kessler, A. L. Landay, and G. M. Shearer. Env-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J. Clin. Invest., 96:867-876, 1995. Helper responses were detected in 75\% of HIV seronegative health care workers, while only 35\% had an HIV specific CTL response. PubMed ID: 7635981. Show all entries for this paper.


Displaying record number 200654

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location Env(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18 IIB
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods Proliferation
Keywords responses in children, mother-to-infant transmission

Notes

References

Kuhn2001a L. Kuhn, S. Meddows-Taylor, G. Gray, D. Trabattoni, M. Clerici, G. M. Shearer, and C. Tiemessen. Reduced HIV-Stimulated T-Helper Cell Reactivity in Cord Blood with Short-Course Antiretroviral Treatment for Prevention of Maternal-Infant Transmission. Clin. Exp. Immunol., 123(3):443-450, Mar 2001. PubMed ID: 11298132. Show all entries for this paper.


Displaying record number 206

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, kinetics, Th1

Notes

References

Wasik2000 T. J. Wasik, A. Wierzbicki, V. E. Whiteman, G. Trinchieri, H. W. Lischner, and D. Kozbor. Association between HIV-specific T helper responses and CTL activities in pediatric AIDS. Eur. J. Immunol., 30:117-27, 2000. PubMed ID: 10602033. Show all entries for this paper.


Displaying record number 210

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1991 M. Clerici, D. R. Lucey, R. A. Zajac, R. N. Boswell, H. M. Gebel, H. Takahashi, J. A. Berzofsky, and G. M. Shearer. Detection of Cytotoxic T Lymphocytes Specific for Synthetic Peptides of gp160 in HIV-Seropositive Individuals. J. Immunol., 146:2214-2219, 1991. Four peptides that could be used to stimulate helper T-cell function were also found to be reactive with MHC class I-restricted CTL in infected individuals. 14 of 20 patients were responsive to at least one of the four peptides. PubMed ID: 1826020. Show all entries for this paper.


Displaying record number 411

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords subtype comparisons, responses in children, mother-to-infant transmission

Notes

References

Kuhn2001 L. Kuhn, A. Coutsoudis, D. Moodley, D. Trabattoni, N. Mngqundaniso, G. M. Shearer, M. Clerici, H. M. Coovadia, and Z. Stein. T-helper cell responses to HIV envelope peptides in cord blood: protection against intrapartum and breast-feeding transmission. AIDS, 15(1):1-9, 5 Jan 2001. PubMed ID: 11192849. Show all entries for this paper.


Displaying record number 217

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1989 M. Clerici, N. I. Stocks, R. A. Zajac, R. N. Boswell, D. C. Bernstein, D. L. Mann, G. M. Shearer, and J. A. Berzofsky. Interleukin-2 Production Used to Detect Antigenic Peptide Recognition by T-Helper Lymphocytes from Asymptomatic HIV-Seropositive Individuals. Nature, 339:383-385, 1989. Notes: Investigation of the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gp160 peptides and to influenza A virus. This paper suggests that a proliferative response is lost in HIV-1 infected individuals prior to the loss of IL-2 production. Env epitopes: T1, T2, TH4.1 and P18. PubMed ID: 2524668. Show all entries for this paper.

Kaul1999 R. Kaul, D. Trabattoni, J. J. Bwayo, D. Arienti, A. Zagliani, F. M. Mwangi, C. Kariuki, E. N. Ngugi, K. S. MacDonald, T. B. Ball, M. Clerici, and F. A. Plummer. HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers. AIDS, 13(1):23-9, 14 Jan 1999. PubMed ID: 10207541. Show all entries for this paper.


Displaying record number 212

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18-IIIB
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Clerici1992 M. Clerici, J. V. Giorgi, C.-C. Chou, V. K. Gudeman, J. A. Zack, P. Gupta, H.-N. Ho, P. G. Nishanian, J. A. Berzofsky, and G. M. Shearer. Cell-Mediated Immune Response to Human Immunodeficiency Virus Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1. J. Infect. Dis., 165:1012-1019, 1992. Notes: Cell-mediated immune response to HIV-1 can be detected in the absence of a humoral immune response in individuals recently exposed to HIV-1. gp160 epitopes: T1, T2, TH4.1, P18-IIIb, P18-MN. PubMed ID: 1533867. Show all entries for this paper.


Displaying record number 200529

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location Env(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18-IIIB
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Country United States
Experimental methods Cytokine production
Keywords mother-to-infant transmission

Notes

References

Clerici1993 M. Clerici, A. V. Sison, J. A. Berzofsky, T. A. Rakusan, C. D. Brandt, M. Ellaurie, M. Villa, C. Colie, D. J. Venzon, and J. L. Sever. Cellular Immune Factors Associated with Mother-to-Infant Transmission of HIV. AIDS, 7(11):1427-1433, Nov 1993. PubMed ID: 8280407. Show all entries for this paper.


Displaying record number 200540

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location HIV-1( IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18IIIB
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods Cytokine production
Keywords Th2

Notes

References

Clerici1994a M. Clerici, T. A. Wynn, J. A. Berzofsky, S. P. Blatt, C. W. Hendrix, A. Sher, R. L. Coffman, and G. M. Shearer. Role of Interleukin-10 in T Helper Cell Dysfunction in Asymptomatic Individuals Infected with the Human Immunodeficiency Virus. J. Clin. Invest., 93(2):768-775, Feb 1994. PubMed ID: 8113410. Show all entries for this paper.


Displaying record number 209

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HXB2 Location gp160(308-322)
gp120(308-322)
DNA(7146..7190)
gp160 Epitope Map
Author Location gp120(315-329 IIIB)
Epitope RIQRGPGRAFVTIGK Epitope Alignment
RIQRGPGRAFVTIGK epitope logo
Epitope Name P18
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1989 M. Clerici, N. I. Stocks, R. A. Zajac, R. N. Boswell, D. C. Bernstein, D. L. Mann, G. M. Shearer, and J. A. Berzofsky. Interleukin-2 Production Used to Detect Antigenic Peptide Recognition by T-Helper Lymphocytes from Asymptomatic HIV-Seropositive Individuals. Nature, 339:383-385, 1989. Notes: Investigation of the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gp160 peptides and to influenza A virus. This paper suggests that a proliferative response is lost in HIV-1 infected individuals prior to the loss of IL-2 production. Env epitopes: T1, T2, TH4.1 and P18. PubMed ID: 2524668. Show all entries for this paper.


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