HIV molecular immunology database


Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 197

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HXB2 Location gp160(308-321)
gp160 Epitope Map
Author Location gp120( MN)
Epitope RIHIGPGRAFYTTK Epitope Alignment
Epitope Name SP10
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  

Vaccine Details

Vaccine type peptide
Vaccine strain B clade MN
Vaccine component Env V3



Klinman1995 D. M. Klinman, B. F. Haynes, and J. Conover. Activation of Interleukin 4- and Interleukin 6-Secreting Cells by HIV-Specific Synthetic Peptides. AIDS Res. Hum. Retroviruses, 11:97-105, 1995. Notes: Immunized mice activate IL-4 and IL-6 producing cells in a dose dependent manner. The V3 region epitope as well as the T1 epitope is able to activate cytokine-producing cells. The order of immunization of T1-SP10 peptides influences the magnitude and cross-reactivity of the response, where the SP10, V3 portion of the immunogen is varied. PubMed ID: 7734201. Show all entries for this paper.

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