Search T Helper/CD4+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 221

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp120( IIIB)
Epitope	`RGPGPAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords	Th1

Vaccine Details

Vaccine type	DNA with CMV promotor
Vaccine strain	B clade IIIB
Vaccine component	gp160, Rev
Adjuvant	IL-2

Notes

Intranasal immunization with IL-2 expression plasmid in addition to DNA vaccine amplifies cellular response to antigen, probably via activation of Th type 1 (Th1) cells.

References

Xin1998 K. Q. Xin, K. Hamajima, S. Sasaki, A. Honsho, T. Tsuji, N. Ishii, X. R. Cao, Y. Lu, J. Fukushima, P. Shapshak, S. Kawamoto, and K. Okuda. Intranasal Administration of Human Immunodeficiency Virus Type-1 (HIV-1) DNA Vaccine with Interleukin-2 Expression Plasmid Enhances Cell-Mediated Immunity against HIV-1. Immunology, 94:438-444, 1998. PubMed ID: 9767429. Show all entries for this paper.

Displaying record number 223

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp120( IIIB)
Epitope	`RGPGPAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords	Th1

Vaccine Details

Vaccine type	DNA with CMV promotor
Vaccine strain	B clade IIIB
Vaccine component	gp160, Rev
Adjuvant	IL-15

Notes

Intranasal immunization with IL-15 expression plasmid in addition to DNA vaccine increases DTH response and CTL activity to the antigen, and decreases the serum IgG1 to IgG2a ratio, enhancing Th type 1 (Th1) cell-mediated immunity.
Expression of IL-2 or IL-15 can enhance Th1 response to the vaccine, but they to do not appear to elicit a synergistic response.

References

Xin1999 K. Q. Xin, K. Hamajima, S. Sasaki, T. Tsuji, S. Watabe, E. Okada, and K. Okuda. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine. Vaccine, 17:858-66, 1999. PubMed ID: 10067692. Show all entries for this paper.

Displaying record number 224

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp120( IIIB)
Epitope	`RGPGPAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords	Th1, Th2

Vaccine Details

Vaccine type	DNA with CMV promotor
Vaccine strain	B clade IIIB
Vaccine component	gp160, Rev
Adjuvant	CD40

Notes

CD40L expression increases DTH, and Th1-dependent responses based on enhanced IgG2a titers, with no lowering of IgG1 titers.
Elispot assay indicated co-injection with hCD40L resulted in greater numbers of IFN-γ producing Th1cells, as well as increased IL-4 producing Th2 cells.
Results suggest hCD40L enhance both Th1 and Th2 cells, and such a pattern of induction is unique among adjuvants, as most adjuvants increase either Th1 or Th2.

References

Ihata1999 A. Ihata, S. Watabe, S. Sasaki, A. Shirai, J. Fukushima, K. Hamajima, J. Inoue, and K. Okuda. Immunomodulatory effect of a plasmid expressing CD40 ligand on DNA vaccination against human immunodeficiency virus type-1. Immunology, 98:436-42, 1999. PubMed ID: 10583605. Show all entries for this paper.