Search T Helper/CD4+ T-Cell Epitope Database

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HXB2 Location	gp160(609-616) gp41(98-105) DNA(8049..8072)	gp160 Epitope Map
Author Location	gp41( consensus)
Epitope	PWNASWSN	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Core region of peptides that can stimulate proliferative responses from seronegative and seropositive people.

References

Mutch1994 D. Mutch, J. Underwood, M. Geysen, and S. Rodda. Comprehensive T-cell epitope mapping of HIV-1 env antigens reveals many areas recognized by HIV-1-seropositive and by low-risk HIV-1-seronegative individuals. J. Acquir. Immune Defic. Syndr., 7(9):879-90, Sep 1994. Notes: The proliferative T-cell response to pools of overlapping 17 mer peptides spanning Env were tested in both seronegative and low risk seropositive people. The pool that gave the greatest number of responders was pool 25, located in gp41. The 17 mer peptides used in this pool were tested individually for their ability to stimulate T-cell proliferation, and the most critical regions were found to be GIWGCSGKLIC and PWNASWSN. Mutch et al. suggest that the proliferative response in HIV-1 seronegative individuals is more likely due to cross-reactive, non-HIV induced memory cells than naive T-cells. PubMed ID: 7519672. Show all entries for this paper.