Search T Helper/CD4+ T-Cell Epitope Database

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HXB2 Location	Pol(288-302) RT(133-147) DNA(2946..2990)	Pol Epitope Map
Author Location	RT(133-147 BRU)
Epitope	`PSINNETPGIRYQYN`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2ⁱ⁵, H-2^k)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade BRU
Vaccine component	RT

Notes

T-cells from RT immunized mice have enhanced proliferative response with peptide.

References

DeGroot1991 A. S. De Groot, M. Clerici, A. Hosmalin, S. H. Hughes, D. Barnd, C. W. Hendrix, R. Houghten, G. M. Shearer, and J. A. Berzofsky. Human Immunodeficiency Virus Reverse Transcriptase T-Helper Epitopes Identified in Mice and Humans: Correlation with a Cytotoxic T Cell Epitope. J. Infect. Dis., 164:1058-1065, 1991. This peptide stimulates both murine helper and cytotoxic T-cells and was able to stimulate IL-2 producing T-cells from 9 out of 17 HIV seropositive humans. RT epitope: CTEMEKEGKISKIGP. PubMed ID: 1720151. Show all entries for this paper.