Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 201271

Download this epitope record as JSON.

HXB2 Location	Vpr(35-49) DNA(5661..5705)	Vpr Epitope Map
Author Location	Vpr(35-49 LAI/IIIB)
Epitope	PRIWLHGLGQHIYET	Epitope Alignment
Epitope Name	Vpr 35-49
Subtype	B
Species (MHC/HLA)	human(DRB5)
Immunogen	in vitro stimulation or selection
Country	France
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity

Notes

• CD4+ T-cell response to Tat and Vpr was evaluated in healthy donors. Most donors responded to both Tat and Vpr. In Tat, for 8 HLA-unrelated donors, only one peptide (KALGISYGRKKRRQR) primed all CD4+ responses, while responses to Vpr involved 6 different peptides, depending on the HLA-DR molecules of the donor.
• Based on binding data and experiments with HLA-DR transfected L cells, this peptide was restricted to DRB5.

References

Castelli2008 Florence A. Castelli, Diane Houitte, Gaetan Munier, Natacha Szely, Alain Lecoq, Jean-Paul Briand, Sylviane Muller, and Bernard Maillere. Immunoprevalence of the CD4+ T-Cell Response to HIV Tat and Vpr Proteins Is Provided by Clustered and Disperse Epitopes, Respectively. Eur. J. Immunol., 38(10):2821-2831, Oct 2008. PubMed ID: 18828138. Show all entries for this paper.