Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201444

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HXB2 Location	gp160(437-446) gp120(437-446) DNA(7533..7562)	gp160 Epitope Map
Author Location
Epitope	PPISGQIRCS	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods	Proliferation
Keywords	glycosylation

Notes

• N-linked glycans essential for recognition of helper epitopes fron C2 and C4 regions were identified by introducing N/Q mutations in the epitope flanking regions.
• 3 CD4 T cell lines, each specific to gp120 CD4 epitope, were generated from chronically infected HIV-1 patients.
• T cell CD4 line specific to C4 epitope PPISGQIRCS, recognized N230Q, N197Q, N234Q mutants as well as the wild type.

References

Li2009b Hualin Li, Chong-Feng Xu, Steven Blais, Qi Wan, Hui-Tang Zhang, Samuel J Landry, and Catarina E. Hioe. Proximal Glycans Outside of the Epitopes Regulate the Presentation of HIV-1 Envelope gp120 Helper Epitopes. J. Immunol, 182(10):6369-6378, 15 May 2009. PubMed ID: 19414790. Show all entries for this paper.