Search T Helper/CD4+ T-Cell Epitope Database

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HXB2 Location	Gag(133-143) p24(1-11) DNA(1186..1218)	Gag Epitope Map
Author Location	p24(1-11 SF2)
Epitope	PIVQNLQGQMV	Epitope Alignment
Epitope Name	p24-1
Subtype	B
Species (MHC/HLA)	human(DR1)
Immunogen	HIV-1 infection
Patient MHC/HLA	Patient 744: A24, A74, B35, B44, DR1, DR12, DR52
Experimental methods
Keywords	escape

Notes

• 43 asymptomatic HIV+ individuals were screened for proliferative responses to HIV -- 12 showed a response, and dominant epitopes were mapped for two individuals, one in p24 and one in p17.
• Out of five truncated versions of peptide PIVQNLQGQMVHQAISPRTL, only p24(1-11) elicited a proliferative response.
• Nine naturally occurring variants of this epitope were found within the individual who made this response -- all bound to HLA-DR1, but three did not stimulate the CD4+ T-cell line that recognized the index peptide, suggestive of immune escape.

References

Harcourt1998 G. C. Harcourt, S. Garrard, M. P. Davenport, A. Edwards, and R. E. Phillips. HIV-1 Variation Diminishes CD4 T Lymphocyte Recognition. J. Exp. Med., 188:1785-1793, 1998. PubMed ID: 9815256. Show all entries for this paper.