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Displaying record number 200519

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HXB2 Location	Gag(133-141) p24(1-9) DNA(1186..1212)	Gag Epitope Map
Author Location	p24(133-141 HXB2)
Epitope	PIVQNIQGQ	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(DRB1*01:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	DQ1, DQ5, DR51, DRB1*01:01, DRB1*15:01
Experimental methods	Intracellular cytokine staining, Proliferation, T-cell Elispot
Keywords	HAART, ART

Notes

• HIV infected individuals with advanced disease often have only weak or undetectable HIV specific Th responses, and HAART can sometimes restore Th HIV recognition in such cases. The repertoire of Th responses to p24 in an individual who responded to HAART after having a CD4+ T-cell count of 0 cells ul was determined. Eleven clonotypes were found among 13 clones, recognizing eight distinct epitopes, with a range of MHC affinities and functional avidities. Multiple Gag p24 peptides were also recognized using CD4 Elispot assays based on samples from six additional HAART-treated CD4 T-cell-reconstituted subjects.
• The TCR that recognized this epitope used Vβ5.1.

References

Boritz2003a Eli Boritz, Brent E. Palmer, Brian Livingston, Alessandro Sette, and Cara C. Wilson. Diverse Repertoire of HIV-1 p24-Specific, IFN-gamma-Producing CD4+ T Cell Clones Following Immune Reconstitution on Highly Active Antiretroviral Therapy. J. Immunol., 170(2):1106-1016, 15 Jan 2003. PubMed ID: 12517980. Show all entries for this paper.