HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 200897

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HXB2 Location Gag(166-181)
p24(34-49)
DNA(1285..1332)
Gag Epitope Map
Author Location p24( HXB2)
Epitope PEVIPMFSALSEGATP Epitope Alignment
PEVIPMFSALSEGATP epitope logo
Subtype B
Species (MHC/HLA) human(DR1)
Immunogen in vitro stimulation or selection
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords epitope processing, vaccine antigen design, characterizing CD8+ T cells

Notes

References

SenGupta2004 Devi SenGupta, Philip J. Norris, Todd J. Suscovich, Mina Hassan-Zahraee, Howell F. Moffett, Alicja Trocha, Rika Draenert, Philip J. R. Goulder, Robert J. Binder, Daniel L. Levey, Bruce D. Walker, Pramod K. Srivastava, and Christian Brander. Heat Shock Protein-Mediated Cross-Presentation of Exogenous HIV Antigen on HLA Class I and Class II. J. Immunol., 173(3):1987-1993, 1 Aug 2004. PubMed ID: 15265933. Show all entries for this paper.


Displaying record number 200976

Download this epitope record as JSON.

HXB2 Location Gag(166-181)
p24(34-49)
DNA(1285..1332)
Gag Epitope Map
Author Location p24(168-177 NY-5)
Epitope PEVIPMFSALSEGATP Epitope Alignment
PEVIPMFSALSEGATP epitope logo
Epitope Name PP16
Subtype B
Species (MHC/HLA) human(DR1)
Immunogen HIV-1 infection
Patient MHC/HLA DQ5, DQ7, DR1, DR11, DRw52
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords rate of progression, acute/early infection, early treatment, variant cross-reactivity

Notes

References

Norris2004 Philip J. Norris, Howell F. Moffett, Christian Brander, Todd M. Allen, Kristin M. O'Sullivan, Lisa A. Cosimi, Daniel E Kaufmann, Bruce D. Walker, and Eric S. Rosenberg. Fine Specificity and Cross-Clade Reactivity of HIV Type 1 Gag-Specific CD4+ T Cells. AIDS Res. Hum. Retroviruses, 20(3):315-325, Mar 2004. PubMed ID: 15117455. Show all entries for this paper.


Displaying record number 201090

Download this epitope record as JSON.

HXB2 Location Gag(166-181)
p24(34-49)
DNA(1285..1332)
Gag Epitope Map
Author Location p24
Epitope PEVIPMFSALSEGATP Epitope Alignment
PEVIPMFSALSEGATP epitope logo
Epitope Name PP16
Species (MHC/HLA) human(DR1)
Immunogen HIV-1 infection
Experimental methods CD4 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation, Tetramer binding
Keywords binding affinity, escape, optimal epitope, antagonism

Notes

References

Norris2006 Philip J. Norris, Jennifer D. Stone, Nadezhda Anikeeva, John W. Heitman, Ingrid C. Wilson, Dale F. Hirschkorn, Margaret J. Clark, Howell F. Moffett, Thomas O. Cameron, Yuri Sykulev, Lawrence J . Stern, and Bruce D. Walker. Antagonism of HIV-Specific CD4+ T Cells by C-Terminal Truncation of a Minimum Epitope. Mol. Immunol., 43(9):1349-1357, Mar 2006. PubMed ID: 16216327. Show all entries for this paper.


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