Search T Helper/CD4+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 170

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HXB2 Location	gp160(220-234) gp120(220-234) DNA(6882..6926)	gp160 Epitope Map
Author Location	gp120(225-240 SF2)
Epitope	`PAGFAILKCNNKTFN`	Epitope Alignment
Species (MHC/HLA)
Immunogen	in vitro stimulation or selection
Experimental methods
Keywords

Notes

T-cell line derived from unprimed, uninfected individual.
Responds to APC pulsed with either synthetic peptide or gp120.
Human MAbs 448-D and 450-D enhance APC gp120 uptake and presentation.

References

Manca1993 F. Manca, E. Seravalli, M. T. Valle, D. Fenoglio, A. Kunkl, G. L. Pira, S. Zolla-Pazner, and F. Celada. Non-Covalent Complexes of HIV gp120 with CD4 and/or mAbs Enhance Activation of gp120-Specific T Clones and Provide Intermolecular Help for Anti-CD4 Antibody Production. Internatl. Immunol., 5:1109-1117, 1993. PubMed ID: 7902128. Show all entries for this paper.

Displaying record number 50556

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HXB2 Location	gp160(220-234) gp120(220-234) DNA(6882..6926)	gp160 Epitope Map
Author Location	gp120( IIIB)
Epitope	`PAGFAILKCNNKTFN`	Epitope Alignment
Epitope Name	pep24
Species (MHC/HLA)	human
Immunogen	vaccine
Experimental methods
Keywords	immunodominance

Vaccine Details

Vaccine type	Streptococcus gordonii
Vaccine component	gp120

Notes

This previously described immunodominant Th cell epitope was fused to the streptococcal surface protein M6 (emm-6.1), for expression on the surface of the bacterium Streptococcus gordonii.
Recombinant bacteria showed efficient MHC class II mediated presentation of gp120 to T-cells by stimulation of a proliferative response in a human T cell clone specific for pep24.

References

Pozzi1994 G. Pozzi, M. R. Oggioni, R. Manganelli, D. Medaglini, V. A. Fischetti, D. Fenoglio, M. T. Valle, A. Kunkl, and F. Manca. Human T-Helper Cell Recognition of an Immunodominant Epitope of HIV-1 gp120 Expressed on the Surface of Streptococcus gordoni. Vaccine, 12(12):1071-1077, Sep 1994. PubMed ID: 7998415. Show all entries for this paper.