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Displaying record number 200899

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HXB2 Location	Gag(271-280) p24(139-148) DNA(1600..1629)	Gag Epitope Map
Author Location	p24(271-280 HZ321)
Epitope	`NKIVRMYSPT`	Epitope Alignment
Subtype	AG
Species (MHC/HLA)	macaque
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses, adjuvant comparison, vaccine antigen design

Vaccine Details

Vaccine type	gp120 depleted virus HZ321 (REMUNE(TM))
Vaccine strain	AG recombinant HZ321
Vaccine component	virus
Adjuvant	Incomplete Freund's Adjuvant (IFA), CpG immunostimulatory sequence (ISS)

Notes

Macaques were immunized with gp120-depleted HIV-1 together with incomplete Freund's adjuvant and CpG-ODN. All four immunized animals had high anti-p24 antibody titers, while three animals showed HIV-1-specific CD4+ and CD8+ T-cell responses. This is one of two CD4+ T-cell epitopes in Gag that was mapped.

References

Silvera2004 Peter Silvera, Jay R. Savary, Virginia Livingston, Jessica White, Kelledy H. Manson, Michael H. Wyand, Peter L. Salk, Ronald B. Moss, and Mark G. Lewis. Vaccination with gp120-Depleted HIV-1 Plus Immunostimulatory CpG Oligodeoxynucleotides in Incomplete Freund's Adjuvant Stimulates Cellular and Humoral Immunity in Rhesus Macaques. Vaccine, 23(6):827-839, 21 Dec 2004. PubMed ID: 15542208. Show all entries for this paper.