Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 200874

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HXB2 Location	Nef(181-188) DNA(9337..9360)	Nef Epitope Map
Author Location	Nef(185-192 SF2)
Epitope	LVWRFDSK	Epitope Alignment
Epitope Name	6.38
Subtype	B
Species (MHC/HLA)	human(DP5)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP5, DQw7, DRw11, DRw52
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.