Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201103

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HXB2 Location	Nef(189-203) DNA(9361..9405)	Nef Epitope Map
Author Location
Epitope	LAFHHVARELHPEYF	Epitope Alignment
Epitope Name	N048
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.