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Displaying record number 201024

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HXB2 Location	Rev(14-30) DNA(6009..6045,8379..8392)	Rev Epitope Map
Author Location	Rev(14-30 B Consensus)
Epitope	KTVRLIKFLYQSNPPPS	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	supervised treatment interruptions (STI), rate of progression, immunodominance, acute/early infection

Notes

• CD4 T-cell responses in 36 HIV-1 positive individuals in different disease stages were mapped by IFN-γ EliSpot using a panel of 410 B-consensus peptides spanning all HIV proteins. Virus specific CD4+ T-cell responses (median=7, range of magnitude=990) were detected in 30/36 patients.
• This peptide was recognized by 11% of the study group.
• Gag and Nef responses dominated the CD4+ T-cell EliSpot responses in the study. No correlation between plasma viremia and the frequency or magnitude of HIV-1-specific responses was observed.
• The most HIV-1 specific CD4+ T-cell responses were observed in acutely infected patients with treatment of primary infection who stopped after 1-3 treatments (acute STI), compared to patients continuing therapy. People with therapy during chronic infection had low responses; higher numbers of responses were seen among untreated people. 2/9 LTNPs responded to many peptides, comparable to acute STI.

References

Kaufmann2004 Daniel E. Kaufmann, Paul M. Bailey, John Sidney, Bradford Wagner, Philip J. Norris, Mary N. Johnston, Lisa A. Cosimi, Marylyn M. Addo, Mathias Lichterfeld, Marcus Altfeld, Nicole Frahm, Christian Brander, Alessandro Sette, Bruce D. Walker, and Eric S. Rosenberg. Comprehensive Analysis of Human Immunodeficiency Virus Type 1-Specific CD4 Responses Reveals Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides. J. Virol., 78(9):4463-4477, May 2004. PubMed ID: 15078927. Show all entries for this paper.