Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 402

Download this epitope record as JSON.

HXB2 Location	Pol(888-902) Integrase(173-187) DNA(4746..4790)	Pol Epitope Map
Author Location	Pol(915-929)
Epitope	KTAVQMAVFFIHNFKR	Epitope Alignment
Epitope Name	Pol 915
Species (MHC/HLA)	human(DR supermotif)
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons

Notes

• Eleven peptides were identified that had the HLA-DR supermotif, all were found to bind to MHC class II DR molecules and all elicited proliferative responses from multiple HIV-infected donors.
• This epitope binds seven HLA-DR alleles: DRB5*0101, DRB1*1302, DRB1*1101, DRB1*0405, DRB1*0401, DRB1*1501 and DRB1*0101, with an IC₅₀ threshold below 1,000 nM.
• This epitope sequence is conserved in 94% of clade B isolates.
• 6/22 HIV infected individuals responded to this epitope (13/22 responded to some of the DR supermotif epitopes, the 9 non-responder peptides tended to also not have recall responses to rec HIV-1 whole proteins)

References

Wilson2001 C. C. Wilson, B. Palmer, S. Southwood, J. Sidney, Y. Higashimoto, E. Appella, R. Chesnut, A. Sette, and B. D. Livingston. Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes. J. Virol., 75(9):4195-207, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/9/4195. PubMed ID: 11287569. Show all entries for this paper.