Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 159

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HXB2 Location	gp160(155-169) gp120(155-169) DNA(6687..6731)	gp160 Epitope Map
Author Location	gp120(160-174 LAI)
Epitope	KNCSFNISTSIRGKV	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(DR)
Immunogen
Experimental methods
Keywords	binding affinity

Notes

• Peptide binds to both HLA-DR*1101 and HLA-DR*0401 with high affinity.
• Because of the distinctive binding pockets of HLA-DR*1101 and HLA-DR*0401, peptides that bound both were considered candidates for promiscuous HLA-DR binding.

References

Gaudebout1997 P. Gaudebout, D. Zeliszewski, J. J. Golvano, C. Pignal, S. Le Gac, F. Borras-Cuesta, and G. Sterkers. Binding Analysis of 95 HIV gp120 Peptides to HLA-DR1101 and -DR0401 Evidenced Many HLA-Class II Binding Regions on gp120 and Suggested Several Promiscuous Regions. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 14(2):91-101, 1997. PubMed ID: 9052717. Show all entries for this paper.