Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 201130

Download this epitope record as JSON.

HXB2 Location	Gag(272-281) p24(140-149) DNA(1603..1632)	Gag Epitope Map
Author Location	Gag(272-281)
Epitope	KIVRMYSPTS	Epitope Alignment
Species (MHC/HLA)	human(DR4)
Immunogen	in vitro stimulation or selection
Experimental methods	Proliferation
Keywords	variant cross-reactivity

Notes

• Cross-reactivity of a human HIV-1 gag-specific CD4+ T cell clone obtained from an HIV-1 seronegative donor was studied using combinatorial peptide library analysis. Peptides from other pathogens were able to activate T cell clone.
• HIV gag peptides with several mutations in KIVRMYSPTS, corresponding to the existing HIV strains were able to strongly activate the T cell clone.
• 2 bacterial peptides from Burkolderia cepacia (KLARLYTPAR) and from Ralstonia picketttii (TLARLYTPVR) activated the T cell clone with the same potency as the HIV peptides.

References

Venturini2006 Sara Venturini, Gina Allicotti, Yindong Zhao, Richard Simon, Dennis R. Burton, Clemencia Pinilla, and Pascal Poignard. Identification of Peptides from Human Pathogens Able to Cross-Activate an HIV-1-Gag-Specific CD4+ T Cell Clone. Eur. J. Immunol., 36(1):27-36, Jan 2006. PubMed ID: 16323241. Show all entries for this paper.