Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 200655

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HXB2 Location	Pol(683-695) RT(528-540) DNA(4131..4169)	Pol Epitope Map
Author Location	RT(528-540)
Epitope	`KEKVYLAWVPAHK`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^b, H-2^d, H-2^k)
Immunogen	vaccine
Experimental methods	Proliferation
Keywords

Vaccine Details

Vaccine type	lipopeptide
Vaccine strain	B clade BRU
Vaccine component	RT
Adjuvant	P3CSS

Notes

BALB/c, C3H/Hej, and C57BL/6 mice were immunized with 22-mer lipopetide tripeptide conjugates P3CSS-[RT-(522-543)] and P3CSS-[RT-(528-549)] of HIV-1 RT, which included the optimal T-helper epitope [RT-(528-540)]. P3CSS conjugated RT epitopes resulted in a specific Th responses, and mice were primed for secondary recognition of native RT. A proximal B cell epitope was also active, containing the motif EQVD.

References

Loleit1996 M. Loleit, H. G. Ihlenfeldt, J. Brunjes, G. Jung, B. Muller, P. Hoffmann, W. G. Bessler, M. Pierres, and G. Haas. Synthetic Peptides Coupled to the Lipotripeptide P3CSS Induce In Vivo B and Thelper Cell Responses to HIV-1 Reverse Transcriptase. Immunobiology, 195(1):61-76, Jan 1996. PubMed ID: 8852601. Show all entries for this paper.