HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 201051

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HXB2 Location Pol(404-418)
RT(249-263)
DNA(3294..3338)
Pol Epitope Map
Author Location (243-263)
Epitope KDSWTVNDIQKLVGK Epitope Alignment
KDSWTVNDIQKLVGK epitope logo
Epitope Name pep23
Species (MHC/HLA) transgenic mouse(DR)
Immunogen vaccine
Experimental methods Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type bacteriophage coat protein, dihydrolipoyl acetyltransferase E2 protein, of Bacillus stearothermophilus
Vaccine component RT

Notes

References

DeBerardinis2003 Piergiuseppe De Berardinis, Rossella Sartorius, Antonella Caivano, Dina Mascolo, Gonzalo J. Domingo, Giovanna Del Pozzo, Muriel Gaubin, Richard N. Perham, Dominique Piatier-Tonneau, and John Guardiola. Use of Fusion Proteins and Procaryotic Display Systems for Delivery of HIV-1 Antigens: Development of Novel Vaccines for HIV-1 Infection. Curr. HIV Res., 1(4):441-446, Oct 2003. PubMed ID: 15049429. Show all entries for this paper.


Displaying record number 429

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HXB2 Location Pol(404-418)
RT(249-263)
DNA(3294..3338)
Pol Epitope Map
Author Location RT(249-263)
Epitope KDSWTVNDIQKLVGK Epitope Alignment
KDSWTVNDIQKLVGK epitope logo
Epitope Name RT2
Species (MHC/HLA) human(DR5)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods  
Keywords epitope processing

Vaccine Details

Vaccine type HIV-1 peptide in filamentous bacteriophage major coat protein
Vaccine component RT

Notes

References

DeBerardinis2000 P. De Berardinis, R. Sartorius, C. Fanutti, R. N. Perham, G. Del Pozzo, and J. Guardiola. Phage Display of Peptide Epitopes from HIV-1 Elicits Strong Cytolytic Responses. Nat. Biotechnol., 18(8):873-876, Aug 2000. PubMed ID: 10932158. Show all entries for this paper.


Displaying record number 200542

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HXB2 Location Pol(404-418)
RT(249-263)
DNA(3294..3338)
Pol Epitope Map
Author Location RT(249-263)
Epitope KDSWTVNDIQKLVGK Epitope Alignment
KDSWTVNDIQKLVGK epitope logo
Epitope Name pep23
Species (MHC/HLA) human, transgenic mouse(DR5)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods Cytokine production, T-cell Elispot, Th support of CTL response
Keywords  

Vaccine Details

Vaccine type peptide presented on icosahedral protein scaffold
Vaccine component RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Domingo2003 Gonzalo J. Domingo, Antonella Caivano, Rossella Sartorius, Pasquale Barba, Malin Bäckström, Dominique Piatier-Tonneau, John Guardiola, Piergiuseppe De Berardinis, and Richard N Perham. Induction of Specific T-Helper and Cytolytic Responses to Epitopes Displayed on a Virus-Like Protein Scaffold Derived from the Pyruvate Dehydrogenase Multienzyme Complex. Vaccine, 21(13-14):1502-1509, 28 Mar 2003. PubMed ID: 12615447. Show all entries for this paper.


Displaying record number 200759

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HXB2 Location Pol(404-418)
RT(249-263)
DNA(3294..3338)
Pol Epitope Map
Author Location RT(248-262)
Epitope KDSWTVNDIQKLVGK Epitope Alignment
KDSWTVNDIQKLVGK epitope logo
Species (MHC/HLA) human(DR5(11.01))
Immunogen in vitro stimulation or selection
Patient MHC/HLA DR5, DR6
Experimental methods Proliferation
Keywords binding affinity, epitope processing, vaccine-induced immune responses, escape

Notes

References

Moschella2003 Federica Moschella, Maria Neve Ombra, Giovanna Del Pozzo, and John Guardiola. Administration of Different Antigenic Forms of Altered Peptide Ligands Derived from HIV-1 RTase Influences Their Effects on T Helper Cell Activation. Hum. Immunol., 64(1):1-8, Jan 2003. PubMed ID: 12507809. Show all entries for this paper.


Displaying record number 200760

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HXB2 Location Pol(404-418)
RT(249-263)
DNA(3294..3338)
Pol Epitope Map
Author Location RT(248-262)
Epitope KDSWTVNDIQKLVGK Epitope Alignment
KDSWTVNDIQKLVGK epitope logo
Species (MHC/HLA) human(DR5(11.01))
Immunogen in vitro stimulation or selection
Patient MHC/HLA DR5, DR6
Experimental methods Proliferation
Keywords binding affinity, epitope processing, vaccine-induced immune responses, escape, TCR usage

Notes

References

Bonomi2000 Giovanna Bonomi, Federica Moschella, Maria Neve Ombra, GGiovanna Del Pozzo, Claude Granier, Piergiuseppe De Berardinis, and John Guardiola. Modulation of TCR Recognition of MHC Class II/Peptide by Processed Remote N- and C-Terminal Epitope Extensions. Hum. Immunol., 61(8):753-763, Aug 2000. PubMed ID: 10980386. Show all entries for this paper.


Displaying record number 83

Download this epitope record as JSON.

HXB2 Location Pol(404-418)
RT(249-263)
DNA(3294..3338)
Pol Epitope Map
Author Location RT(248-262)
Epitope KDSWTVNDIQKLVGK Epitope Alignment
KDSWTVNDIQKLVGK epitope logo
Species (MHC/HLA) human
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

DeBerardinis1999 P. De Berardinis, L. D'Apice, A. Prisco, M. N. Ombra, P. Barba, G. Del Pozzo, S. Petukhov, P. Malik, R. N. Perham, and J. Guardiola. Recognition of HIV-Derived B and T Cell Epitopes Displayed on Filamentous Phages. Vaccine, 17:1434-1441, 1999. PubMed ID: 10195779. Show all entries for this paper.

Manca1995 F. Manca, D. Fenoglio, M. T. Valle, G. L. Pira, A. Kunkl, R. S. Balderas, R. G. Baccala, D. H. Kono, A. Ferraris, D. Saverino, F. Lancia, L. Lozzi, and A. N. Theofilopoulos. Human T helper cells specific for HIV reverse transcriptase: possible role in intrastructural help for HIV envelope-specific antibodies. Eur. J. Immunol., 25:1217-1223, 1995. PubMed ID: 7539750. Show all entries for this paper.


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