Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201884

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HXB2 Location	Gag(333-347) p24(201-215) DNA(1786..1830)	Gag Epitope Map
Author Location	Gag
Epitope	ILKALGPGATLEEMM	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	in vitro stimulation or selection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, Other
Keywords	binding affinity, novel epitope

Notes

• Ex vivo-expanded HIV-specific T cells and antigen presenting cells from seronegative donors were identified against specific Gag or Nef epitopes with the goal of using them in allogenic hematopoietic stem cell transplantation. This is the first domonstration of ex vivo-primed and expanded HIV-specific T cells releasing IFNγ in response to mapped epitopes, with enhanced ability to suppress HIV replication in vitro.
• This is the first domonstration of ex vivo-primed and expanded HIV-specific T cells releasing IFNγ in response to epitope , and with enhanced ability to suppress HIV replication in vitro.
• Novel Gag epitope ILKALGPGATLEEMM was found to elicit Helper T cell immune response in a seronegative donor.

References

Patel2016 Shabnum Patel, Sharon Lam, Conrad Russell Cruz, Kaylor Wright, Christina Cochran, Richard F. Ambinder, and Catherine M. Bollard. Functionally Active HIV-Specific T Cells that Target Gag and Nef Can Be Expanded from Virus-Naive Donors and Target a Range of Viral Epitopes: Implications for a Cure Strategy after Allogeneic Hematopoietic Stem Cell Transplantation. Biol. Blood Marrow Transplant., 22(3):536-541, Mar 2016. PubMed ID: 26721209. Show all entries for this paper.