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Displaying record number 50620

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HXB2 Location	Pol(681-695) RT(526-540) DNA(4125..4169)	Pol Epitope Map
Author Location	RT(526-540 BRU)
Epitope	`IKKEKVYLAWVPAHK`	Epitope Alignment
Epitope Name	W9
Subtype	B
Species (MHC/HLA)	mouse(H-2 A^d, H-2D^d)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	peptide, protein, inactivated HIV
Vaccine strain	B clade BRU
Vaccine component	RT, virus
Adjuvant	Complete Freund's Adjuvant (CFA)

Notes

Of 5 mouse inbred lines tested: DBA/2 (H-2d, Ad, Ed), B10.A(4R) (H-2h4, Ak) and B10.A(5R) (H-2i5) showed particularly good CD4+ T cell proliferative responses to HIV proteins (gp160, gp120, p17, p24, Nef and RT), after vaccination with inactivated virus.
B10.BR (H-2k, Ak, Ek) and C57BL/6 (H-2b and Ab) had weaker responses.
The peptide KEKVYLAWVPAHKG was one of two RT peptides with Th cells recognition.

References

Haas1991 G. Haas, R. David, R. Frank, H. Gausepohl, C. Devaux, J.-M. Claverie, and M. Pierres. Identification of a Major Human Immunodeficiency Virus-1 Reverse Transcriptase Epitope Recognized by Mouse CD4+ T Lymphocytes. Eur. J. Immunol., 21:1371-1377, 1991. Notes: RT peptides were recognized by several of the T-helper lines established from RT-primed mice. Further, T-cells from peptide-primed mice could be restimulated by native RT. RT epitope: KEKVYLAWVPAHKGIG. PubMed ID: 1710563. Show all entries for this paper.