Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 201066

Download this epitope record as JSON.

HXB2 Location	Gag(33-47) p17(33-47) DNA(886..930)	Gag Epitope Map
Author Location	Gag(33-47 HXB-2)
Epitope	HIVWASRELERFAVN	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	DQB1*03:01, DQB1*06:01, DRB1*13:03, DRB1*15:02, DRB3*01:01, DRB5*01:02
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords

Notes

• The study measured CD4+ T-cell responses against epitopes in Gag p17 and p24 and concurrent endogenous plasma HIV-1 RNA epitope sequence variation. No intrapatient protein sequence variation was found in identified epitopes, indicating that escape from CD4-positive T-cell responses is not a common process in vivo.
• 1/22 patients responded to this peptide.

References

Koeppe2006 John R. Koeppe, Thomas B. Campbell, Eric L. Rapaport, and Cara C. Wilson. HIV-1-Specific CD4+ T-Cell Responses Are Not Associated With Significant Viral Epitope Variation in Persons With Persistent Plasma Viremia. J. Acquir. Immune Defic. Syndr., 41(2):140-148, 1 Feb 2006. PubMed ID: 16394844. Show all entries for this paper.