HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 445

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp160(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Species (MHC/HLA) mouse(H-2k)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB
Vaccine component gp160
Adjuvant Complete Freund's Adjuvant (CFA)

Notes

References

Berzofsky1991 J. A. Berzofsky, C. D. Pendleton, M. Clerici, J. Ahlers, D. R. Lucey, S. D. Putney, and G. M. Shearer. Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types. Trans. Assoc. Am. Physicians, 104:69-77, 1991. PubMed ID: 1845157. Show all entries for this paper.

Berzofsky1991a J. A. Berzofsky, C. D. Pendleton, M. Clerici, J. Ahlers, D. R. Lucey, S. D. Putney, and G. M. Shearer. Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types. J. Clin. Invest., 88(3):876-84, Sep 1991. PubMed ID: 1715888. Show all entries for this paper.


Displaying record number 141

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) mouse(H-2k)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Hale1989 P. M. Hale, K. B. Cease, R. A. Houghten, C. Ouyang, S. Putney, K. Javaherian, H. Margalit, J. L. Cornette, J. L. Spouge, C. DeLisi, and et. al. T Cell Multideterminant Regions in the Human Immunodeficiency Virus Envelope: Toward Overcoming the Problem of Major Histocompatibility Complex Restriction. Int. Immunol., 1(4):409-415, 1989. PubMed ID: 2484961. Show all entries for this paper.


Displaying record number 142

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 BH10)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) mouse(H-2k, H-2s)
Immunogen computer prediction
Experimental methods Other
Keywords computational epitope prediction

Notes

References

Cease1987 K. B. Cease, H. Margalit, J. L. Cornette, S. D. Putney, W. G. Robey, C. Ouyang, H. Z. Streicher, P. J. Fischinger, R. C. Gallo, C. DeLisi, and et. al. Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide. Proc. Natl. Acad. Sci. U.S.A., 84(12):4249-53, Jun 1987. An algorithm based on a model of immunodominant helper T-cell sites forming amphipathic helices was used to identify for the first time two T-cell sites, env T1 and env T2. These two peptides were shown to stimulate proliferation of T-cells in mice immunized with a fragment of the env protein. Also, mice immunized with T1 were able to induce immunity to env gp120. Multiple haplotypes were responsive. Env epitopes: T2: HEDIISLWDQSLK and T1: KQIINMWQEVGKAMYA. PubMed ID: 2438696. Show all entries for this paper.


Displaying record number 146

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Clerici1991b M. Clerici, C. O. Tacket, C. S. Via, D. R. Lucey, S. C. Muluk, R. A. Zajac, R. N. Boswell, J. A. Berzofsky, and G. M. Shearer. Immunization with Subunit Human Immunodeficiency Virus Vaccine Generates Stronger T Helper Cell Immunity than Natural Infection. Eur. J. Immunol., 21:1345-1349, 1991. Notes: Immunization of uninfected individuals with an HIV subunit vaccine results in stronger Th cell immunity than does natural infection. Boosting enhances helper function. Env epitopes: T1, T2, TH4.1, P18. PubMed ID: 1845391. Show all entries for this paper.


Displaying record number 143

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 BH10)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Berzofsky1988 J. A. Berzofsky, A. Bensussan, K. B. Cease, J. F. Bourge, R. Cheynier, Z. Lurhama, J.-J. Salaun, R. C. Gallo, G. M. Shearer, and D. Zagury. Antigenic Peptides Recognized by T Lymphocytes from AIDS Viral Envelope-Immune Humans. Nature, 334:706-708, 1988. Notes: Test of response to synthetic peptides of lymphocytes from 14 healthy human volunteers who had been immunized with a rec vaccinia virus containing HIV gp160, then boosted with a recombinant fragment containing the carboxyl-terminal 40\% of gp120. 8/14 showed a proliferative response to T1; 4/14 to T2. A reduced response to T2 in terms of both magnitude and frequency may have been because of the boost containing the region covering T1, but not T2, and because of the timing of sampling relative to immunization. Some HLA typing was done but no conclusive MHC restriction patterns were determined. Env epitopes: T1: KQIINMWQEVGLAMYA and T2: HEDIISLWDQSLK. PubMed ID: 2457809. Show all entries for this paper.


Displaying record number 408

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords subtype comparisons, responses in children, mother-to-infant transmission

Notes

References

Kuhn2001 L. Kuhn, A. Coutsoudis, D. Moodley, D. Trabattoni, N. Mngqundaniso, G. M. Shearer, M. Clerici, H. M. Coovadia, and Z. Stein. T-helper cell responses to HIV envelope peptides in cord blood: protection against intrapartum and breast-feeding transmission. AIDS, 15(1):1-9, 5 Jan 2001. PubMed ID: 11192849. Show all entries for this paper.


Displaying record number 145

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1991 M. Clerici, D. R. Lucey, R. A. Zajac, R. N. Boswell, H. M. Gebel, H. Takahashi, J. A. Berzofsky, and G. M. Shearer. Detection of Cytotoxic T Lymphocytes Specific for Synthetic Peptides of gp160 in HIV-Seropositive Individuals. J. Immunol., 146:2214-2219, 1991. Four peptides that could be used to stimulate helper T-cell function were also found to be reactive with MHC class I-restricted CTL in infected individuals. 14 of 20 patients were responsive to at least one of the four peptides. PubMed ID: 1826020. Show all entries for this paper.


Displaying record number 140

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1997 M. Clerici, S. Piconi, C. Balotta, D. Trabattoni, A. Capetti, M. L. Fusi, S. Ruzzante, R. Longhi, M. C. Colombo, M. Moroni, and F. Milazzo. Pentoxifylline Improves Cell-Mediated Immunity and Reduces Human Immunodeficiency Virus (HIV) Plasma Viremia in Asymptomatic HIV-Seropositive Persons. J. Infect. Dis., 175:1210-1215, 1997. PubMed ID: 9129088. Show all entries for this paper.


Displaying record number 200538

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location HIV-1( IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods Cytokine production
Keywords Th2

Notes

References

Clerici1994a M. Clerici, T. A. Wynn, J. A. Berzofsky, S. P. Blatt, C. W. Hendrix, A. Sher, R. L. Coffman, and G. M. Shearer. Role of Interleukin-10 in T Helper Cell Dysfunction in Asymptomatic Individuals Infected with the Human Immunodeficiency Virus. J. Clin. Invest., 93(2):768-775, Feb 1994. PubMed ID: 8113410. Show all entries for this paper.


Displaying record number 200527

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location Env(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Country United States
Experimental methods Cytokine production
Keywords mother-to-infant transmission

Notes

References

Clerici1993 M. Clerici, A. V. Sison, J. A. Berzofsky, T. A. Rakusan, C. D. Brandt, M. Ellaurie, M. Villa, C. Colie, D. J. Venzon, and J. L. Sever. Cellular Immune Factors Associated with Mother-to-Infant Transmission of HIV. AIDS, 7(11):1427-1433, Nov 1993. PubMed ID: 8280407. Show all entries for this paper.


Displaying record number 201001

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location Env (gp160)(105-117)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name TH2
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods Proliferation
Keywords responses in children, variant cross-reactivity

Notes

References

Meddows-Taylor2004 Stephen Meddows-Taylor, Maria A. Papathanasopoulos, Louise Kuhn, Tammy M. Meyers, and Caroline T. Tiemessen. Detection of Human Immunodeficiency Virus Type 1 Envelope Peptide-Stimulated T-Helper Cell Responses and Variations in the Corresponding Regions of Viral Isolates among Vertically Infected Children. Virus Genes, 28(3):311-318, Apr 2004. PubMed ID: 15266112. Show all entries for this paper.


Displaying record number 200533

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Subtype B
Species (MHC/HLA)  
Immunogen HIV-1 exposed seronegative
Experimental methods Cytokine production
Keywords  

Notes

References

Clerici1994 M. Clerici, J. M. Levin, H. A. Kessler, A. Harris, J. A. Berzofsky, A. L. Landay, and G. M. Shearer. HIV-Specific T-Helper Activity in Seronegative Health Care Workers Exposed to Contaminated Blood. JAMA, 271(1):42-46, 5 Jan 1994. PubMed ID: 8258885. Show all entries for this paper.


Displaying record number 148

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide prime with protein boost
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Hosmalin1991 A. Hosmalin, P. L. Nara, M. Zweig, M. W. Lerche, K. B. Cease, E. A. Gard, P. D. Markham, S. D. Putney, M. D. Daniel, R. C. Desrosiers, and J. A. Berzofsky. Priming with T-Helper Cell Epitope Peptides Enhances the Antibody Response to the Envelope Glycoprotein of HIV-1 in Primates. J. Immunol., 146:1667-1673, 1991. Notes: Induction of T-cell help in rhesus monkeys it Macaca mulatta by priming with peptides T2 or TH4.1 enhances antibody response to a subsequent suboptimal gp160 immunization. T1 alone failed to elicit a response in these experiments. Env epitopes: T1, T2, TH4.1. PubMed ID: 1704401. Show all entries for this paper.


Displaying record number 147

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Clerici1992 M. Clerici, J. V. Giorgi, C.-C. Chou, V. K. Gudeman, J. A. Zack, P. Gupta, H.-N. Ho, P. G. Nishanian, J. A. Berzofsky, and G. M. Shearer. Cell-Mediated Immune Response to Human Immunodeficiency Virus Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1. J. Infect. Dis., 165:1012-1019, 1992. Notes: Cell-mediated immune response to HIV-1 can be detected in the absence of a humoral immune response in individuals recently exposed to HIV-1. gp160 epitopes: T1, T2, TH4.1, P18-IIIb, P18-MN. PubMed ID: 1533867. Show all entries for this paper.


Displaying record number 150

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1989 M. Clerici, N. I. Stocks, R. A. Zajac, R. N. Boswell, D. C. Bernstein, D. L. Mann, G. M. Shearer, and J. A. Berzofsky. Interleukin-2 Production Used to Detect Antigenic Peptide Recognition by T-Helper Lymphocytes from Asymptomatic HIV-Seropositive Individuals. Nature, 339:383-385, 1989. Notes: Investigation of the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gp160 peptides and to influenza A virus. This paper suggests that a proliferative response is lost in HIV-1 infected individuals prior to the loss of IL-2 production. Env epitopes: T1, T2, TH4.1 and P18. PubMed ID: 2524668. Show all entries for this paper.

Kaul1999 R. Kaul, D. Trabattoni, J. J. Bwayo, D. Arienti, A. Zagliani, F. M. Mwangi, C. Kariuki, E. N. Ngugi, K. S. MacDonald, T. B. Ball, M. Clerici, and F. A. Plummer. HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers. AIDS, 13(1):23-9, 14 Jan 1999. PubMed ID: 10207541. Show all entries for this paper.


Displaying record number 144

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Clerici1989 M. Clerici, N. I. Stocks, R. A. Zajac, R. N. Boswell, D. C. Bernstein, D. L. Mann, G. M. Shearer, and J. A. Berzofsky. Interleukin-2 Production Used to Detect Antigenic Peptide Recognition by T-Helper Lymphocytes from Asymptomatic HIV-Seropositive Individuals. Nature, 339:383-385, 1989. Notes: Investigation of the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gp160 peptides and to influenza A virus. This paper suggests that a proliferative response is lost in HIV-1 infected individuals prior to the loss of IL-2 production. Env epitopes: T1, T2, TH4.1 and P18. PubMed ID: 2524668. Show all entries for this paper.


Displaying record number 200650

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location Env(112-124)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods Proliferation
Keywords responses in children, mother-to-infant transmission

Notes

References

Kuhn2001a L. Kuhn, S. Meddows-Taylor, G. Gray, D. Trabattoni, M. Clerici, G. M. Shearer, and C. Tiemessen. Reduced HIV-Stimulated T-Helper Cell Reactivity in Cord Blood with Short-Course Antiretroviral Treatment for Prevention of Maternal-Infant Transmission. Clin. Exp. Immunol., 123(3):443-450, Mar 2001. PubMed ID: 11298132. Show all entries for this paper.


Displaying record number 149

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HXB2 Location gp160(105-117)
gp120(105-117)
DNA(6537..6575)
gp160 Epitope Map
Author Location gp120(112-124 IIIB)
Epitope HEDIISLWDQSLK Epitope Alignment
HEDIISLWDQSLK epitope logo
Epitope Name T2
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, Cytokine production
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Pinto1995 L. A. Pinto, J. Sullivan, J. A. Berzofsky, M. Clerici, H. A. Kessler, A. L. Landay, and G. M. Shearer. Env-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J. Clin. Invest., 96:867-876, 1995. Helper responses were detected in 75\% of HIV seronegative health care workers, while only 35\% had an HIV specific CTL response. PubMed ID: 7635981. Show all entries for this paper.


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