Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 50562

Download this epitope record as JSON.

HXB2 Location	Tat(33-48) DNA(5927..5974)	Tat Epitope Map
Author Location	Tat(33-48 HXB2)
Epitope	HCQVCFITKALGISYG	Epitope Alignment
Epitope Name	D28
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• 9/14 (64%) of HIV-1 positive patients had proliferative T-cell responses associated with IL-2 production against at least one Tat-derived synthetic peptides of twelve overlapping 15-16 mer peptides spanning Tat. T cell proliferation was associated with IL-2 production.
• 3/12 peptides were recognized.
• 4/14 HIV+ people recognized this peptide.
• An alpha-helix structure was predicted at residues 39-44, but charge patterns did not indicate it was an amphipathic helix, suggested to be most favorable for T-cell epitopes.
• This peptide contained epitopes restricted by several HLA DR alleles, although the frequency of DR5 was enriched (2/4) among the patients that recognized the peptide.

References

Blazevic1993 V. Blazevic, A. Ranki, S. Mattinen, S. L. Valle, S. Koskimies, G. Jung, and K. J. Krohn. Helper T-cell Recognition of HIV-1 Tat Synthetic Peptides. J. Acquir. Immune Defic. Syndr., 6(8):881-890, Aug 1993. PubMed ID: 7686223. Show all entries for this paper.