HIV molecular immunology database


Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 23

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HXB2 Location Gag(219-233)
Gag Epitope Map
Author Location p24(219-233 BRU)
Epitope HAGPIAPGQMREPRG Epitope Alignment
Species (MHC/HLA) mouse(H-2b)
Immunogen in vitro stimulation or selection
Experimental methods  



Vaslin1994 B. Vaslin, J.-M. Claverie, O. Benveniste, F. C. Barre-Sinoussi, and D. Dormont. Nef and Gag Synthetic Peptide Priming of Antibody Responses to HIV Type 1 Antigens in Mice and Primates. AIDS Res. Hum. Retroviruses, 10:1241-1250, 1994. Notes: Four Gag peptides, that when pooled are able to prime for subsequent antibody response to HIV in mice, were studied. These peptides were also able to prime it in vitro immunoproliferative responses. The two peptides of the four that were able to prime humoral responses to inactivated HIV-1 are included in the table (G2 and G4) -- the other two are not included (G1 and G3). Three proposed nef helper T-cell epitopes are also not included in the table, but may be of interest. These nef peptides could prime the humoral response in mice, but not it it in vitro proliferation. Priming was also observed in baboons, using the pool of four Gag peptides. PubMed ID: 7531460. Show all entries for this paper.

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