HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 201520

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HXB2 Location Gag(233-247)
p24(101-115)
DNA(1486..1530)
Gag Epitope Map
Author Location Gag(233-247 HXB2)
Epitope GSDIAGTTSTLQEQI Epitope Alignment
GSDIAGTTSTLQEQI epitope logo
Subtype B
Species (MHC/HLA) transgenic mouse(DRB1*01:01)
Immunogen vaccine
Experimental methods T-cell Elispot
Keywords vaccine-induced immune responses, dendritic cells

Vaccine Details

Vaccine type DNA prime with peptide boost, DNA
Vaccine strain B clade HXB2
Vaccine component Gag

Notes

References

Simon2010 Gregory G. Simon, Yongli Hu, Asif M. Khan, Jingshi Zhou, Jerome Salmon, Priya R. Chikhlikar, Keun-Ok Jung, Ernesto T. A. Marques, and J. Thomas August. Dendritic Cell Mediated Delivery of Plasmid DNA Encoding LAMP/HIV-1 Gag Fusion Immunogen Enhances T Cell Epitope Responses in HLA DR4 Transgenic Mice. PLoS One, 5(1):e8574, 2010. PubMed ID: 20052293. Show all entries for this paper.


Displaying record number 26

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HXB2 Location Gag(233-247)
p24(101-115)
DNA(1486..1530)
Gag Epitope Map
Author Location p24(235-249 SF2)
Epitope GSDIAGTTSTLQEQI Epitope Alignment
GSDIAGTTSTLQEQI epitope logo
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type virus-like particle (VLP)
Vaccine strain B clade SF2
Vaccine component p24 Gag

Notes

References

Mills1990 K. H. G. Mills, A. L. Barnard, B. P. Mahon, P. A. Kitchin, S. E. Adams, S. M. Kingsman, and A. J. Kingsman. Induction of HIV-Specific Immune Responses in Primates: Fine Specificity of Antibody and Helper T-Cell Recognition of the HIV p24 Protein. Vaccines, 90:213-218, 1990. Notes: Four cynomolgous macaques were immunized with 3 doses of p24 TY virus-like particles and their immune response was followed. Three 15 mer peptides stimulated CD4 T-cells proliferation and IL-2 production. Two of these responses were verified at the clonal level. B-cell responses were also studied in this paper. Show all entries for this paper.


Displaying record number 201068

Download this epitope record as JSON.

HXB2 Location Gag(233-247)
p24(101-115)
DNA(1486..1530)
Gag Epitope Map
Author Location Gag(233-247 HXB-2)
Epitope GSDIAGTTSTLQEQI Epitope Alignment
GSDIAGTTSTLQEQI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA DQB1*03:01, DQB1*06:01, DRB1*13:03, DRB1*15:02, DRB3*01:01, DRB5*01:02
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords  

Notes

References

Koeppe2006 John R. Koeppe, Thomas B. Campbell, Eric L. Rapaport, and Cara C. Wilson. HIV-1-Specific CD4+ T-Cell Responses Are Not Associated With Significant Viral Epitope Variation in Persons With Persistent Plasma Viremia. J. Acquir. Immune Defic. Syndr., 41(2):140-148, 1 Feb 2006. PubMed ID: 16394844. Show all entries for this paper.


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