Search T Helper/CD4+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 201520

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HXB2 Location	Gag(233-247) p24(101-115) DNA(1486..1530)	Gag Epitope Map
Author Location	Gag(233-247 HXB2)
Epitope	GSDIAGTTSTLQEQI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	transgenic mouse(DRB1*01:01)
Immunogen	vaccine
Experimental methods	T-cell Elispot
Keywords	vaccine-induced immune responses, dendritic cells

Vaccine Details

Notes

• Dendritic cell mediated immunization of DNA plasmid constructs was studied in BALB/c (H-2d) and HLA-DR4 (DRA1*0101, DRB1*0401) transgenic mice. Most peptide-specific T-cell responses in the HLA-DR4 transgenic mice corresponded to human HLA-DR4 epitopes listed in HIV Immunology Database.
• Gag peptide GSDIAGTTSTLQEQI elicited CD4 T-cell responses in HLA-DR4 (DRB1*0401) transgenic mice immunized with pLAMP/gag-based prime and boost formulations.

References

Simon2010 Gregory G. Simon, Yongli Hu, Asif M. Khan, Jingshi Zhou, Jerome Salmon, Priya R. Chikhlikar, Keun-Ok Jung, Ernesto T. A. Marques, and J. Thomas August. Dendritic Cell Mediated Delivery of Plasmid DNA Encoding LAMP/HIV-1 Gag Fusion Immunogen Enhances T Cell Epitope Responses in HLA DR4 Transgenic Mice. PLoS One, 5(1):e8574, 2010. PubMed ID: 20052293. Show all entries for this paper.

Displaying record number 26

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HXB2 Location	Gag(233-247) p24(101-115) DNA(1486..1530)	Gag Epitope Map
Author Location	p24(235-249 SF2)
Epitope	GSDIAGTTSTLQEQI	Epitope Alignment
Species (MHC/HLA)	macaque
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• Responses to 3 T-cell and multiple linear B-cell epitopes were found in vaccinated macaques -- epitope response defined by T-cell clone.

References

Mills1990 K. H. G. Mills, A. L. Barnard, B. P. Mahon, P. A. Kitchin, S. E. Adams, S. M. Kingsman, and A. J. Kingsman. Induction of HIV-Specific Immune Responses in Primates: Fine Specificity of Antibody and Helper T-Cell Recognition of the HIV p24 Protein. Vaccines, 90:213-218, 1990. Notes: Four cynomolgous macaques were immunized with 3 doses of p24 TY virus-like particles and their immune response was followed. Three 15 mer peptides stimulated CD4 T-cells proliferation and IL-2 production. Two of these responses were verified at the clonal level. B-cell responses were also studied in this paper. Show all entries for this paper.

Displaying record number 201068

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HXB2 Location	Gag(233-247) p24(101-115) DNA(1486..1530)	Gag Epitope Map
Author Location	Gag(233-247 HXB-2)
Epitope	GSDIAGTTSTLQEQI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	DQB1*03:01, DQB1*06:01, DRB1*13:03, DRB1*15:02, DRB3*01:01, DRB5*01:02
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords

Notes

• The study measured CD4+ T-cell responses against epitopes in Gag p17 and p24 and concurrent endogenous plasma HIV-1 RNA epitope sequence variation. No intrapatient protein sequence variation was found in identified epitopes, indicating that escape from CD4-positive T-cell responses is not a common process in vivo.
• 1/22 patients responded to this peptide.

References

Koeppe2006 John R. Koeppe, Thomas B. Campbell, Eric L. Rapaport, and Cara C. Wilson. HIV-1-Specific CD4+ T-Cell Responses Are Not Associated With Significant Viral Epitope Variation in Persons With Persistent Plasma Viremia. J. Acquir. Immune Defic. Syndr., 41(2):140-148, 1 Feb 2006. PubMed ID: 16394844. Show all entries for this paper.