HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 201752

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HXB2 Location Gag(435-452)
p2p7p1p6(72-89)
DNA(2092..2145)
Gag Epitope Map
Author Location Gag
Epitope GKIWPSHKGRPGNFLQSR Epitope Alignment
GKIWPSHKGRPGNFLQSR epitope logo
Epitope Name OLP-60
Species (MHC/HLA) human(DRB1*07:01, DRB1*13:01, DRB1*15:01)
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, HLA cross-presentation

Notes

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.


Displaying record number 201038

Download this epitope record as JSON.

HXB2 Location Gag(435-452)
p2p7p1p6(72-89)
DNA(2092..2145)
Gag Epitope Map
Author Location p15(72-89 B Consensus)
Epitope GKIWPSHKGRPGNFLQSR Epitope Alignment
GKIWPSHKGRPGNFLQSR epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords supervised treatment interruptions (STI), rate of progression, immunodominance, acute/early infection

Notes

References

Kaufmann2004 Daniel E. Kaufmann, Paul M. Bailey, John Sidney, Bradford Wagner, Philip J. Norris, Mary N. Johnston, Lisa A. Cosimi, Marylyn M. Addo, Mathias Lichterfeld, Marcus Altfeld, Nicole Frahm, Christian Brander, Alessandro Sette, Bruce D. Walker, and Eric S. Rosenberg. Comprehensive Analysis of Human Immunodeficiency Virus Type 1-Specific CD4 Responses Reveals Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides. J. Virol., 78(9):4463-4477, May 2004. PubMed ID: 15078927. Show all entries for this paper.


Displaying record number 201412

Download this epitope record as JSON.

HXB2 Location Gag(435-452)
p2p7p1p6(72-89)
DNA(2092..2145)
Gag Epitope Map
Author Location p15
Epitope GKIWPSHKGRPGNFLQSR Epitope Alignment
GKIWPSHKGRPGNFLQSR epitope logo
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords immunodominance

Notes

References

Ramduth2009 Danni Ramduth, Cheryl L. Day, Christina F. Thobakgale, Nompumelelo P. Mkhwanazi, Chantal de Pierres, Sharon Reddy, Mary van der Stok, Zenele Mncube, Kriebashne Nair, Eshia S. Moodley, Daniel E. Kaufmann, Hendrik Streeck, Hoosen M. Coovadia, Photini Kiepiela, Philip J. R. Goulder, and Bruce D. Walker. Immunodominant HIV-1 CD4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection. PLoS One, 4(4):e5013, 2009. PubMed ID: 19352428. Show all entries for this paper.


Displaying record number 201489

Download this epitope record as JSON.

HXB2 Location Gag(435-452)
p2p7p1p6(72-89)
DNA(2092..2145)
Gag Epitope Map
Author Location Gag
Epitope GKIWPSHKGRPGNFLQSR Epitope Alignment
GKIWPSHKGRPGNFLQSR epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Germany, United States
Experimental methods Flow cytometric T-cell cytokine assay
Keywords elite controllers

Notes

References

Chevalier2011 Mathieu F. Chevalier, Boris Jülg, Augustine Pyo, Michael Flanders, Srinika Ranasinghe, Damien Z. Soghoian, Douglas S. Kwon, Jenna Rychert, Jeffrey Lian, Matthias I. Muller, Sam Cutler, Elizabeth McAndrew, Heiko Jessen, Florencia Pereyra, Eric S. Rosenberg, Marcus Altfeld, Bruce D. Walker, and Hendrik Streeck. HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function. J. Virol., 85(2):733-741, Jan 2011. PubMed ID: 21047960. Show all entries for this paper.


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