HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 307

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HXB2 Location gp160(594-604)
gp41(83-93)
DNA(8004..8036)
gp160 Epitope Map
Author Location gp41( consensus)
Epitope GIWGCSGKLIC Epitope Alignment
GIWGCSGKLIC epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Mutch1994 D. Mutch, J. Underwood, M. Geysen, and S. Rodda. Comprehensive T-cell epitope mapping of HIV-1 env antigens reveals many areas recognized by HIV-1-seropositive and by low-risk HIV-1-seronegative individuals. J. Acquir. Immune Defic. Syndr., 7(9):879-90, Sep 1994. Notes: The proliferative T-cell response to pools of overlapping 17 mer peptides spanning Env were tested in both seronegative and low risk seropositive people. The pool that gave the greatest number of responders was pool 25, located in gp41. The 17 mer peptides used in this pool were tested individually for their ability to stimulate T-cell proliferation, and the most critical regions were found to be GIWGCSGKLIC and PWNASWSN. Mutch et al. suggest that the proliferative response in HIV-1 seronegative individuals is more likely due to cross-reactive, non-HIV induced memory cells than naive T-cells. PubMed ID: 7519672. Show all entries for this paper.


Displaying record number 201200

Download this epitope record as JSON.

HXB2 Location gp160(594-604)
gp41(83-93)
DNA(8004..8036)
gp160 Epitope Map
Author Location  
Epitope GIWGCSGKLIC Epitope Alignment
GIWGCSGKLIC epitope logo
Show epitope variants
Subtype B, BF, C
Species (MHC/HLA) human
Immunogen virus
Country Brazil
Experimental methods  
Keywords subtype comparisons, viral fitness and reversion

Notes

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.


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