HIV molecular immunology database
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|gp160 Epitope Map|
Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.