Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201129

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HXB2 Location	gp160(620-634) gp41(109-123) DNA(8082..8126)	gp160 Epitope Map
Author Location	Env(620-634 HXB2)
Epitope	EQIWNHTTWMEWDRE	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(DP4)
Immunogen	in vitro stimulation or selection
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, epitope processing, computational epitope prediction, dendritic cells

Notes

• Motif-based quantitative matrices binding predictions, binding assays and cellular assays were used to identify 4 HLA-DP4 epitopes by scanning the whole HIV-1 genome.
• 21 peptides were predicted to bind HLA-DP4, 17 of them did bind in binding assays, 6 of them were good binders. Of the 6 good binders, 4 peptides primed peptide-specific CD4+ T cell lines restricted to HLA-DP4 molecules.

References

Cohen2006 William M Cohen, Sandra Pouvelle-Moratille, Xiao-Fei Wang, Sandrine Farci, Gaetan Munier, Dominique Charron, André Ménez, Marc Busson, and Bernard Maillère. Scanning the HIV Genome for CD4+ T Cell Epitopes Restricted to HLA-DP4, the Most Prevalent HLA Class II Molecule. J Immunol, 176(9):5401-5408, 1 May 2006. PubMed ID: 16622007. Show all entries for this paper.