Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201354

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HXB2 Location	gp160(211-225) gp120(211-225) DNA(6855..6899)	gp160 Epitope Map
Author Location
Epitope	`EPIPIHYCAPAGFAI`	Epitope Alignment
Subtype	B, D
Species (MHC/HLA)	mouse
Immunogen	vaccine
Experimental methods	Cytokine production
Keywords	epitope processing

Vaccine Details

Vaccine type	DNA prime with protein boost
Vaccine strain	B clade 1007, D clade UG92005
Vaccine component	gp140

Notes

Murine hybridomas with known Env peptide specificities were tested for IL-2 production following stimulation with autologous splenocytes exposed to HIV-1-infected CXCR4 GHOST cells. Hybridomas were originally derived from C57BL/6 mice immunized with a prime-boost regimen. Antigen-processing potentials in the mouse system were studied.
The presence of a target sequence within HIV-1 did not ensure T-cell reactivity. Subtype of immunogen used to elicit T-cell reactivity also did not predict T-cell responsiveness.
EPIPIHYCAPAGFAI was the target sequence for hybridoma 1007P1-89 and precisely matched HIV-1 pNL43 sequence infecting GHOST cells. But the hybridoma was unresponsive to EPIPIHYCAPAGFAI.

References

Sealy2008 Robert Sealy, Wendy Chaka, Sherri Surman, Scott A. Brown, Peter Cresswell, and Julia L. Hurwitz. Target Peptide Sequence within Infectious Human Immunodeficiency Virus Type 1 Does Not Ensure Envelope-Specific T-Helper Cell Reactivation: Influences of Cysteine Protease and Gamma Interferon-Induced Thiol Reductase Activities. Clin. Vaccine Immunol., 15(4):713-719, Apr 2008. PubMed ID: 18235043. Show all entries for this paper.