HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 201432

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HXB2 Location Pol(684-698)
RT(529-543)
DNA(4134..4178)
Pol Epitope Map
Author Location Pol(711-)
Epitope EKVYLAWVPAHKGIG Epitope Alignment
EKVYLAWVPAHKGIG epitope logo
Epitope Name Pol711
Species (MHC/HLA) transgenic mouse(DR)
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type polyepitope
Vaccine component Env, Gag, Pol, Vpu

Notes

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.


Displaying record number 50539

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HXB2 Location Pol(684-698)
RT(529-543)
DNA(4134..4178)
Pol Epitope Map
Author Location Pol(711-725)
Epitope EKVYLAWVPAHKGIG Epitope Alignment
EKVYLAWVPAHKGIG epitope logo
Epitope Name Pol 711
Species (MHC/HLA) mouse(DR, I-Ab)
Immunogen vaccine
Patient MHC/HLA H-2b
Experimental methods  
Keywords vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA with CMV promotor, peptide
Adjuvant Complete Freund's Adjuvant (CFA)

Notes

References

Livingston2002 Brian Livingston, Claire Crimi, Mark Newman, Yuichiro Higashimoto, Ettore Appella, John Sidney, and Alessandro Sette. A Rational Strategy to Design Multiepitope Immunogens Based on Multiple Th Lymphocyte Epitopes. J. Immunol., 168(11):5499-5506, 1 Jun 2002. PubMed ID: 12023344. Show all entries for this paper.


Displaying record number 405

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HXB2 Location Pol(684-698)
RT(529-543)
DNA(4134..4178)
Pol Epitope Map
Author Location Pol(711-725)
Epitope EKVYLAWVPAHKGIG Epitope Alignment
EKVYLAWVPAHKGIG epitope logo
Epitope Name Pol 711
Species (MHC/HLA) human(DR supermotif)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Wilson2001 C. C. Wilson, B. Palmer, S. Southwood, J. Sidney, Y. Higashimoto, E. Appella, R. Chesnut, A. Sette, and B. D. Livingston. Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes. J. Virol., 75(9):4195-207, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/9/4195. PubMed ID: 11287569. Show all entries for this paper.


Displaying record number 200938

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HXB2 Location Pol(684-698)
RT(529-543)
DNA(4134..4178)
Pol Epitope Map
Author Location Protease-RT(711-725)
Epitope EKVYLAWVPAHKGIG Epitope Alignment
EKVYLAWVPAHKGIG epitope logo
Epitope Name Pol4
Species (MHC/HLA) human(DR supermotif)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining, Proliferation
Keywords rate of progression, superinfection

Notes

References

Boaz2003 M. J. Boaz, A. Waters, S. Murad, P. J. Easterbrook, E. D'Sousa, C. van Wheeley, and A. Vyakarnam. CD4 Responses to Conserved HIV-1 T Helper Epitopes Show Both Negative and Positive Associations with Virus Load in Chronically Infected Subjects. Clin. Exp. Immunol., 134(3):454-463, Dec 2003. PubMed ID: 14632751. Show all entries for this paper.


Displaying record number 201836

Download this epitope record as JSON.

HXB2 Location Pol(684-698)
RT(529-543)
DNA(4134..4178)
Pol Epitope Map
Author Location Pol
Epitope EKVYLAWVPAHKGIG Epitope Alignment
EKVYLAWVPAHKGIG epitope logo
Epitope Name Pol711
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods Other, Proliferation
Keywords vaccine-induced immune responses, vaccine antigen design, junction or fusion peptide, Synthetic peptide

Notes

References

Kashi2014 Venkatesh P. Kashi, Rajesh A. Jacob, Raghavendra A. Shamanna, Malini Menon, Anangi Balasiddaiah, Rebu K. Varghese, Mahesh Bachu, and Udaykumar Ranga. The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile. PLoS One, 9(12):e114155, 2014. PubMed ID: 25531437. Show all entries for this paper.


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