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Displaying record number 201365

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HXB2 Location	Gag(260-269) p24(128-137) DNA(1567..1596)	Gag Epitope Map
Author Location	p24(128-137)
Epitope	`EIYRWIILG`	Epitope Alignment
Species (MHC/HLA)	human(DRB113:01, DRB113:02)
Immunogen	vaccine
Country	Russia
Experimental methods	T-cell Elispot
Keywords	vaccine antigen design

Vaccine Details

Vaccine type	DNA, virus-like particle (VLP), HIV infected-cell lysate, polyepitope
Vaccine component	Env, Gag, Nef, Pol

Notes

Two immunogens were combined in the CombiHIV vac (VLP-TBI-pcDNATCI) vaccine: artificial polyepitope protein TBI, containing T- and B-cell epitopes from Env and Gag and the DNA vaccine construct pcDNA-TCI, carrying CTL and CD4+ epitopes from Env, Gag, Pol, Nef.
Combination of two B- and T-cell immunogens resulted in increase in the antibody response (but not CTL response) to both TBI protein and the proteins from HIV-1 lysate, compared to the level of antibodies induced by immunization with either immunogen alone. The synergistic effect in the induction of B-cell-mediated response was explained by the presence of CD4+ T-helper epitopes in TCI, due to stimulation of B-cell proliferation and differentiation.
EIYRWIILG is a previously known epitope that is a part of TCI fragment NPPIPVGEIYRWIILGLNKIVRMYSPTSI in this vaccine construct.

References

Bazhan2008 Sergei I. Bazhan, Larisa I. Karpenko, Leonid R. Lebedev, Roman V. Uzhachenko, Pavel A. Belavin, Alexey M. Eroshkin, and Alexander A. Ilyichev. A Synergistic Effect of a Combined Bivalent DNA-Protein Anti-HIV-1 Vaccine Containing Multiple T- and B-Cell Epitopes of HIV-1 Proteins. Mol. Immunol., 45(3):661-669, Feb 2008. PubMed ID: 17869341. Show all entries for this paper.