Search T Helper/CD4+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 201513

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HXB2 Location	Gag(73-87) p17(73-87) DNA(1006..1050)	Gag Epitope Map
Author Location	Gag(73-87 HXB2)
Epitope	EELRSLYNTVATLYC	Epitope Alignment
Subtype	B
Species (MHC/HLA)	transgenic mouse(DRB1*01:01)
Immunogen	vaccine
Experimental methods	T-cell Elispot
Keywords	vaccine-induced immune responses, dendritic cells

Vaccine Details

Notes

• Dendritic cell mediated immunization of DNA plasmid constructs was studied in BALB/c (H-2d) and HLA-DR4 (DRA1*0101, DRB1*0401) transgenic mice. Most peptide-specific T-cell responses in the HLA-DR4 transgenic mice corresponded to human HLA-DR4 epitopes listed in HIV Immunology Database.
• Gag peptide EELRSLYNTVATLYC elicited CD4 T-cell responses in HLA-DR4 (DRB1*0401) transgenic mice immunized with pLAMP/gag-based prime and boost formulations.

References

Simon2010 Gregory G. Simon, Yongli Hu, Asif M. Khan, Jingshi Zhou, Jerome Salmon, Priya R. Chikhlikar, Keun-Ok Jung, Ernesto T. A. Marques, and J. Thomas August. Dendritic Cell Mediated Delivery of Plasmid DNA Encoding LAMP/HIV-1 Gag Fusion Immunogen Enhances T Cell Epitope Responses in HLA DR4 Transgenic Mice. PLoS One, 5(1):e8574, 2010. PubMed ID: 20052293. Show all entries for this paper.

Displaying record number 201418

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HXB2 Location	Gag(73-87) p17(73-87) DNA(1006..1050)	Gag Epitope Map
Author Location	p17
Epitope	EELRSLYNTVATLYC	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	OM296:
Country	Canada
Experimental methods	CD4 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords	acute/early infection

Notes

• IL-2 producing CD4 T cells were studied in 3 acutely infected HIV-1 infected subjects. Despite the early presence of IL-2 producing T cells, each subject exhibited progressive disease, one subject showing rapid progression. In this rapid progressor 3 IL-2 producing CD4 T-cell responses were identified, mapped to optimal epitopes and further studied.
• EELRSLYNTVATLYC was targeted by IL-2 producing T cell clone in subject OM296 (37 years old male, viral load 10,691 copies/ml), sampled less than 4 months postinfection.

References

Jones2009 R. Brad Jones, Feng-Yun Yue, Xiao Xiao Jenny Gu, Diana V. Hunter, Shariq Mujib, Gabor Gyenes, Rosemarie D. Mason, Ruqaya Mohamed, Kelly S. MacDonald, Colin Kovacs, and Mario A. Ostrowski. Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4+ T-Cell Responses without High-Frequency Fixation of Mutations. J. Virol., 83(17):8722-8732, Sep 2009. PubMed ID: 19553327. Show all entries for this paper.