Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 200552

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HXB2 Location	Gag(295-307) p24(163-175) DNA(1672..1710)	Gag Epitope Map
Author Location	Gag(295-307)
Epitope	DYVDRFYKTLRAE	Epitope Alignment
Species (MHC/HLA)	human(DR0101)
Immunogen	HIV-1 infection
Experimental methods	CD4 T-cell Elispot - IFNγ, Cytokine production, Proliferation, Tetramer binding
Keywords	HAART, ART, supervised treatment interruptions (STI)

Notes

• Fifteen patients recieving HAART with strong CD4+ proliferative responses to HIV antigens while on therapy were examined, to see the effects of viremia on these responses during treatment interruptions. Increased viremia occurred in 12/15 patients during at least one treatment interruption. Anti-HIV proliferative responses were inhibited during viremia, but IFNgamma production to Gag, Pol, and Nef peptide pools were maintained.
• IL-2 production diminished during viremia, and exogenous IL-2 revived in vitro proliferation of HIV-specific T-cells to Gag or Pol DR0101 epitopes in a tetramer, as well as Gag-specific total CD4 T-cell responses.

References

Iyasere2003 Christiana Iyasere, John C. Tilton, Alison J. Johnson, Souheil. Younes, Bader. Yassine-Diab, Rafick-Pierre. Sekaly, William W. Kwok, Stephen A. Migueles, Alisha C. Laborico, W. Lesley Shupert, Claire W. Hallahan, Richard T. Davey, Jr., Mark Dybul, Susan Vogel, Julia Metcalf, and Mark Connors. Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+ T Cells is Associated with Diminished Interleukin-2 (IL-2) Production and is Recovered by Exogenous IL-2. J. Virol., 77(20):10900-10909, Oct 2003. PubMed ID: 14512540. Show all entries for this paper.