Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201000

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HXB2 Location	gp160(827-841) gp41(316-330) DNA(8703..8747)	gp160 Epitope Map
Author Location	Env (gp160)(421-436)
Epitope	DRVIEVVGQAYRAIR	Epitope Alignment
Epitope Name	TH4.1
Subtype	C
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	Proliferation
Keywords	responses in children, variant cross-reactivity

Notes

• Viral isolates (gp160) from 16 vertically HIV-1 infected children (8 T-helper cell Env responders and 8 non-responders) were analyzed for variation after comparison with Env peptide sequences (conserved regions T1, T2 and TH4.1, hypervariable regions P18 MN and P181 IIIB) used for in vitro stimulation.
• No correlation between the age, clinical category (mild or severe), HIV-1 viral load and the degree of epitope variation was established.

References

Meddows-Taylor2004 Stephen Meddows-Taylor, Maria A. Papathanasopoulos, Louise Kuhn, Tammy M. Meyers, and Caroline T. Tiemessen. Detection of Human Immunodeficiency Virus Type 1 Envelope Peptide-Stimulated T-Helper Cell Responses and Variations in the Corresponding Regions of Viral Isolates among Vertically Infected Children. Virus Genes, 28(3):311-318, Apr 2004. PubMed ID: 15266112. Show all entries for this paper.