Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 201202

Download this epitope record as JSON.

HXB2 Location	Gag(298-310) p24(166-178) DNA(1681..1719)	Gag Epitope Map
Author Location	p24
Epitope	DRFFKTLRAEQAT	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, vaccine
Country	United Kingdom
Experimental methods	CD4 T-cell Elispot - IFNγ, Intracellular cytokine staining, Proliferation
Keywords	HAART, ART, vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Notes

• A vaccinia-gag vaccine stimulated broad functional T helper responses in 16 chronically infected HAART patients. Gag-specific CD4+ T cell responses targeted known and new epitopes, several of which were also recognized by HIV-uninfected subjects.
• Both DRFFKTLRAEQAT and FFKTLRAEQATQE stimulated stronger response than 15-mer originally tested peptide DRFFKTLRAEQATQE. Peptides lacking FKTLRAEQA (FKTLRAEQATQEVKNW and RDYVDRFFKTLRAEQA) did not stimulate a response, suggesting that the FKTLRAEQA, which fits the predicted peptide-binding motif for HLA-DRB1*1301 and *1302, represented the core binding region of two distinct epitopes in this region.

References

Ondondo2006 Beatrice O. Ondondo, Hongbing Yang, Tao Dong, Kati di Gleria, Annie Suttill, Christopher Conlon, Denise Brown, Patricia Williams, Sarah L Rowland-Jones, Tomáš Hanke, Andrew J McMichael, and Lucy Dorrell. Immunisation with Recombinant Modified Vaccinia Virus Ankara Expressing HIV-1 gag in HIV-1-Infected Subjects Stimulates Broad Functional CD4+ T Cell Responses. Eur. J. Immunol., 36(10):2585-2594, Oct 2006. PubMed ID: 17013989. Show all entries for this paper.