HIV molecular immunology database


Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 308

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HXB2 Location gp160(598-609)
gp160 Epitope Map
Author Location gp41(603-614 LAI)
Epitope CSGKLICTTAVP Epitope Alignment
CSGKLICTTAVP epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  



Schrier1989 R. D. Schrier, J. W. Gnann, R. Landes, C. Lockshin, D. Richman, A. McCutchan, C. Kennedy, M. B. A. Oldstone, and J. A. Nelson. T-Cell Recognition of HIV Synthetic Peptides in a Natural Infection. J. Immunol., 142:1166-1176, 1989. Notes: The ability of 21 peptides to stimulate T-cell proliferation was tested in 30 HIV-infected donors in different clinical stages. T-cells from 27/30 donors were able to respond to at least one peptide. Two of the peptides were able to stimulate proliferation in 48\% of the donors. Schrier it et al. did not write down the peptide sequences they used, but only provided the numbering of the boundaries on a reference sequence (LAI, Wain-Hobson it et al., Cell 40:9-17 (1985)). In our experience, such numbering is often imprecise, so the peptide assignments in this database may be off by several residues. Two epitopes that Schrier it et al. mistakenly labeled as p24 peptides are instead p15 peptides. PubMed ID: 2783706. Show all entries for this paper.

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