Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 196

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HXB2 Location	gp160(303-319) gp120(303-319) DNA(7131..7181)	gp160 Epitope Map
Author Location	gp120( subtype C)
Epitope	CKRKIHIGPGQAFYT	Epitope Alignment
Subtype	C
Species (MHC/HLA)	mouse(H-2b, H-2d, H-2k, H-2s)
Immunogen	HIV-1 infection
Experimental methods
Keywords	Th1

Notes

• A V3 loop peptide modified to resemble an Indian form (GPGQ) was incorporated into ISCOMS (immune stimulating complexes) or liposomes, and used to immunize mice -- the IgG2a/IgG2b Ab response was enhanced by the presentation in the ISCOM suggestive of a Th1 response.

References

Ahluwalia1997 A. Ahluwalia, K. Gokulan, I. Nath, and D. N. Rao. Modification of delivery system enhances MHC nonrestricted immunogenicity of V3 loop region of HIV-1 gp120. Microbiol. Immunol., 41:779-84, 1997. PubMed ID: 9403501. Show all entries for this paper.