Search T Helper/CD4+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 463

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HXB2 Location	gp160(821-835) gp41(310-324) DNA(8685..8729)	gp160 Epitope Map
Author Location	gp160(828-842 IIIB)
Epitope	AVAEGTDRVIEVVQG	Epitope Alignment
Species (MHC/HLA)	mouse(H-2b, H-2k, H-2s)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• This peptide elicited proliferative responses in cells from B10.BR mice (H-2A^k, E^k), B10.A(5R) mice (H-2A^b, E^b), and B10.S(9R) mice (H-2A^s, E^s)
• AVAEGTDRVIEVVQGAYRAIRHIPRRIRQGLER encompasses several murine Th epitopes including AVAEGTDRVIEVVQG and is referred to as a "multideterminant region" or cluster peptide.

References

Berzofsky1991 J. A. Berzofsky, C. D. Pendleton, M. Clerici, J. Ahlers, D. R. Lucey, S. D. Putney, and G. M. Shearer. Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types. Trans. Assoc. Am. Physicians, 104:69-77, 1991. PubMed ID: 1845157. Show all entries for this paper.

Berzofsky1991a J. A. Berzofsky, C. D. Pendleton, M. Clerici, J. Ahlers, D. R. Lucey, S. D. Putney, and G. M. Shearer. Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types. J. Clin. Invest., 88(3):876-84, Sep 1991. PubMed ID: 1715888. Show all entries for this paper.

Displaying record number 323

Download this epitope record as JSON.

HXB2 Location	gp160(821-835) gp41(310-324) DNA(8685..8729)	gp160 Epitope Map
Author Location	gp41(828-842 IIIB)
Epitope	AVAEGTDRVIEVVQG	Epitope Alignment
Species (MHC/HLA)	mouse(H-2k)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• Six multideterminant helper T-cell regions are recognized by mice of three or four MHC types.

References

Hale1989 P. M. Hale, K. B. Cease, R. A. Houghten, C. Ouyang, S. Putney, K. Javaherian, H. Margalit, J. L. Cornette, J. L. Spouge, C. DeLisi, and et. al. T Cell Multideterminant Regions in the Human Immunodeficiency Virus Envelope: Toward Overcoming the Problem of Major Histocompatibility Complex Restriction. Int. Immunol., 1(4):409-415, 1989. PubMed ID: 2484961. Show all entries for this paper.