HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 201511

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HXB2 Location Gag(37-51)
p17(37-51)
DNA(898..942)
Gag Epitope Map
Author Location Gag(37-51 HXB2)
Epitope ASRELERFAVNPGLL Epitope Alignment
ASRELERFAVNPGLL epitope logo
Subtype B
Species (MHC/HLA) transgenic mouse(DRB1*01:01)
Immunogen vaccine
Experimental methods T-cell Elispot
Keywords vaccine-induced immune responses, dendritic cells

Vaccine Details

Vaccine type DNA prime with peptide boost, DNA
Vaccine strain B clade HXB2
Vaccine component Gag

Notes

References

Simon2010 Gregory G. Simon, Yongli Hu, Asif M. Khan, Jingshi Zhou, Jerome Salmon, Priya R. Chikhlikar, Keun-Ok Jung, Ernesto T. A. Marques, and J. Thomas August. Dendritic Cell Mediated Delivery of Plasmid DNA Encoding LAMP/HIV-1 Gag Fusion Immunogen Enhances T Cell Epitope Responses in HLA DR4 Transgenic Mice. PLoS One, 5(1):e8574, 2010. PubMed ID: 20052293. Show all entries for this paper.


Displaying record number 201008

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HXB2 Location Gag(37-51)
p17(37-51)
DNA(898..942)
Gag Epitope Map
Author Location p17(37-51 B consensus)
Epitope ASRELERFAVNPGLL Epitope Alignment
ASRELERFAVNPGLL epitope logo
Subtype B
Species (MHC/HLA) human(DRB1*01:01, DRB1*04:01, DRB1*04:05, DRB1*07:01, DRB1*13:02, DRB1*15:01)
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords supervised treatment interruptions (STI), rate of progression, immunodominance, acute/early infection

Notes

References

Kaufmann2004 Daniel E. Kaufmann, Paul M. Bailey, John Sidney, Bradford Wagner, Philip J. Norris, Mary N. Johnston, Lisa A. Cosimi, Marylyn M. Addo, Mathias Lichterfeld, Marcus Altfeld, Nicole Frahm, Christian Brander, Alessandro Sette, Bruce D. Walker, and Eric S. Rosenberg. Comprehensive Analysis of Human Immunodeficiency Virus Type 1-Specific CD4 Responses Reveals Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides. J. Virol., 78(9):4463-4477, May 2004. PubMed ID: 15078927. Show all entries for this paper.


Displaying record number 201750

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HXB2 Location Gag(37-51)
p17(37-51)
DNA(898..942)
Gag Epitope Map
Author Location Gag
Epitope ASRELERFAVNPGLL Epitope Alignment
ASRELERFAVNPGLL epitope logo
Epitope Name OLP-6
Species (MHC/HLA) human(DRB1*13:01, DRB1*13:02, DRB4*01:01)
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, HLA cross-presentation

Notes

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.


Displaying record number 201635

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HXB2 Location Gag(37-51)
p17(37-51)
DNA(898..942)
Gag Epitope Map
Author Location p17(37-51)
Epitope ASRELERFAVNPGLL Epitope Alignment
ASRELERFAVNPGLL epitope logo
Epitope Name OLP 6
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords immunodominance, elite controllers, novel epitope

Notes

References

Ranasinghe2012 Srinika Ranasinghe, Michael Flanders, Sam Cutler, Damien Z. Soghoian, Musie Ghebremichael, Isaiah Davis, Madelene Lindqvist, Florencia Pereyra, Bruce D. Walker, David Heckerman, and Hendrik Streeck. HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome. J. Virol., 86(1):277-283, Jan 2012. PubMed ID: 22031937. Show all entries for this paper.


Displaying record number 201864

Download this epitope record as JSON.

HXB2 Location Gag(37-51)
p17(37-51)
DNA(898..942)
Gag Epitope Map
Author Location p17
Epitope ASRELERFAVNPGLL Epitope Alignment
ASRELERFAVNPGLL epitope logo
Epitope Name Peptide 6
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Germany, United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords immunodominance, acute/early infection, chronic infection

Notes

References

Schieffer2014 Miriam Schieffer, Heiko K. Jessen, Alexander F. Oster, Franco Pissani, Damien Z. Soghoian, Richard Lu, Arne B. Jessen, Carmen Zedlack, Bruce T. Schultz, Isaiah Davis, Srinika Ranasinghe, Eric S. Rosenberg, Galit Alter, Ralf R. Schumann, and Hendrik Streeck. Induction of Gag-specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control. J. Virol., 88(13):7357-7366, Jul 2014. PubMed ID: 24741089. Show all entries for this paper.


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