Search T Helper/CD4+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 337

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HXB2 Location	gp160(839-848) gp41(328-337) DNA(8739..8768)	gp160 Epitope Map
Author Location	gp41(846-855 IIIB)
Epitope	`AIRHIPRRIR`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d, H-2^t4)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine strain	B clade IIIB
Vaccine component	gp160

Notes

Suggested H-2^d,t4 epitope based on region of overlap.

References

Hale1989 P. M. Hale, K. B. Cease, R. A. Houghten, C. Ouyang, S. Putney, K. Javaherian, H. Margalit, J. L. Cornette, J. L. Spouge, C. DeLisi, and et. al. T Cell Multideterminant Regions in the Human Immunodeficiency Virus Envelope: Toward Overcoming the Problem of Major Histocompatibility Complex Restriction. Int. Immunol., 1(4):409-415, 1989. PubMed ID: 2484961. Show all entries for this paper.

Displaying record number 201383

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HXB2 Location	gp160(839-848) gp41(328-337) DNA(8739..8768)	gp160 Epitope Map
Author Location	gp41(839-848)
Epitope	`AIRHIPRRIR`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d, H-2^t4)
Immunogen	vaccine
Country	Russia
Experimental methods	T-cell Elispot
Keywords	vaccine antigen design

Vaccine Details

Vaccine type	DNA, virus-like particle (VLP), HIV infected-cell lysate, polyepitope
Vaccine component	Env, Gag, Nef, Pol

Notes

Two immunogens were combined in the CombiHIV vac (VLP-TBI-pcDNATCI) vaccine: artificial polyepitope protein TBI, containing T- and B-cell epitopes from Env and Gag and the DNA vaccine construct pcDNA-TCI, carrying CTL and CD4+ epitopes from Env, Gag, Pol, Nef.
Combination of two B- and T-cell immunogens resulted in increase in the antibody response (but not CTL response) to both TBI protein and the proteins from HIV-1 lysate, compared to the level of antibodies induced by immunization with either immunogen alone. The synergistic effect in the induction of B-cell-mediated response was explained by the presence of CD4+ T-helper epitopes in TCI, due to stimulation of B-cell proliferation and differentiation.
AIRHIPRRIR is a previously known epitope that is a part of TCI fragment SLLNATDIAVAEGTDRVIEVVQGAYRAIRHIPRRIRQGLERILL in this vaccine construct.

References

Bazhan2008 Sergei I. Bazhan, Larisa I. Karpenko, Leonid R. Lebedev, Roman V. Uzhachenko, Pavel A. Belavin, Alexey M. Eroshkin, and Alexander A. Ilyichev. A Synergistic Effect of a Combined Bivalent DNA-Protein Anti-HIV-1 Vaccine Containing Multiple T- and B-Cell Epitopes of HIV-1 Proteins. Mol. Immunol., 45(3):661-669, Feb 2008. PubMed ID: 17869341. Show all entries for this paper.